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Classification of low-grade B-cell lymphomas
Cyclin D1 is a protein that regulates entry of the cell into cell cycle. It drives the transition between G0 and G1 phase. In normal tissues, basal epithelial cells, endothelial cells, and stromal cells are often cyclin D1 positive. As a result of a translocation involving the cyclin D1 gene and IgH, t(11;14), the vast majority of mantle cell lymphomas overexpress cyclin D1. This is a useful feature in the classification of low-grade B-cell lymphomas.
This test does not include pathologist interpretation; only technical performance of the stain is performed. If an interpretation is required, order PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case.
The positive and negative controls are verified as showing appropriate immunoreactivity and documentation is retained at Mayo Clinic Rochester. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request, call 855-516-8404.
Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Age of a cut paraffin section can affect immunoreactivity. Stability thresholds vary widely among published literature and are antigen-dependent. Best practice is for paraffin sections to be cut fresh.
1. Salem Amir M, et al: Prognostic value of combined; Cox-2, cyclin D1 and P21 expression in colorectal cancer (CRC) patients: An immunohistochemical study. Open J Pathol. 2018;8(3):106-121
2. Parvin T, et al: Prognostic utility of cyclin D1 in invasive breast carcinoma. Indian J Surg Oncol. 2019;10(1):167-173
3. Li Z, et al: Prognostic significance of cyclin D1 expression in renal cell carcinoma: a systematic review and meta-analysis. Pathol Oncol Res. 2020;26(3):1401-1409