Test Catalog

Test ID: CLUS    
Clusterin Immunostain, Technical Component Only

Useful For Suggests clinical disorders or settings where the test may be helpful

A marker of follicular dendritic cells

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

In lymph nodes, tonsils, and spleen, clusterin stains the follicular dendritic cell meshworks. B cells, T cells, and histiocytes are negative. Clusterin is often positive in the tumor cells of systemic anaplastic large-cell lymphoma and is usually negative in Reed Sternberg cells in classical Hodgkin lymphoma. It is a sensitive marker for follicular dendritic cell sarcomas.

Interpretation Provides information to assist in interpretation of the test results

This test includes only technical performance of the stain (no pathologist interpretation is performed). Mayo Clinic cannot provide an interpretation of tech only stains outside the context of a pathology consultation. If an interpretation is needed, refer to PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case. All material associated with the case is required. Additional specific stains may be requested as part of the pathology consultation, and will be performed as necessary at the discretion of the Mayo pathologist.


The positive and negative controls are verified as showing appropriate immunoreactivity and documentation is retained at Mayo Clinic Rochester. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request. Contact 855-516-8404.


Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Age of a cut paraffin section can affect immunoreactivity. Stability thresholds vary widely among published literature and are antigen-dependent. Best practice is for paraffin sections to be cut fresh.

Clinical Reference Recommendations for in-depth reading of a clinical nature

1. Grogg KL, Lae ME, Kurtin PJ, Macon WR: Clusterin expression distinguishes follicular dendritic cell tumors from other dendritic cell neoplasms. Am J Surg Pathol 2004;28(8):988-998

2. Grogg KL, Macon WR, Kurtin PJ, Nascimento AG: A survey of clusterin and fascin expression in sarcomas and spindle cell neoplasms: Strong Clusterin Immunostaining is Highly Specific for Follicular Dendritic Cell Tumor. Modern Pathology 2005;18:260-266

3. Saffer H, Wahed A, Rassidakis GZ, Medieros J: Clusterin expression in malignant lymphomas: A Survey of 266 Cases. Modern Pathology 2002;15(11):1221-1226