Test Catalog

Test ID: CD57    
CD57 Immunostain, Technical Component Only

Useful For Suggests clinical disorders or settings where the test may be helpful

Marker of natural killer cells and a subset of follicular T helper cells


Aiding in the identification of tumors of neuroectodermal origin

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

CD57 (cluster of differentiation 57) is present in tumors of neuroectodermal origins; small cell lung carcinoma, carcinoid tumors, adenocarcinomas of the prostate. It is also expressed in normal and hyperplastic prostatic epitheliums as well as in natural killer (NK) cells and a subset of T cells.

Interpretation Provides information to assist in interpretation of the test results

This test does not include pathologist interpretation; only technical performance of the stain is performed. If an interpretation is required, order PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case.


The positive and negative controls are verified as showing appropriate immunoreactivity and documentation is retained at Mayo Clinic Rochester. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request. Contact 855-516-8404.


Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Age of a cut paraffin section can affect immunoreactivity. Stability thresholds vary widely among published literature and are antigen-dependent. Best practice is for paraffin sections to be cut within 6 weeks.

Clinical Reference Recommendations for in-depth reading of a clinical nature

1. Fang J, Li X, Ma D, et al: Prognostic significance of tumor infiltrating immune cells in oral squamous cell carcinoma. BMC Cancer. 2017;375(17)

2. Greenberg SA, Pinkus JL, Amato AA, Kristensen T, Dorfman DM: Association of inclusion body myositis with T cell large granular lymphocytic leukaemia. Brain. 2016 May;139(5):1348-1360

3. David JA, Huang JZ: Diagnostic utility of flow cytometry analysis of reactive T cells in nodular lymphocyte-predominant Hodgkin lymphoma. Am J Clin Pathol. 2016 Jan;145(1):107-115