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Aids in the diagnosis of hairy cell leukemia and marginal zone lymphomas
CD103, also known as integrin alpha E, is an integrin subunit protein, which is widely expressed on T cells. CD103 is a useful diagnostic tool in the diagnosis of hairy cell leukemia.
This test does not include pathologist interpretation; only technical performance of the stain. If interpretation is required order PATHC / Pathology Consultation for a full diagnostic evaluation or second opinion of the case.
The positive and negative controls are verified as showing appropriate immunoreactivity and documentation is retained at Mayo Clinic Rochester. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request. Contact 855-516-8404.
Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Age of a cut paraffin section can affect immunoreactivity. Stability thresholds vary widely among published literature and are antigen-dependent. Best practice is for paraffin sections to be cut within 6 weeks.
1. Morgan EA, Yu H, Pinkus JL, Pinkus GS: Immunohistochemical detection of hairy cell leukemia in paraffin sections using a highly effective CD103 rabbit monoclonal antibody. Am J Clin Pathol. 2013;139:220-230
2. Shao H, Calvo KR, Gronborg M, et al: Distinguishing hairy cell leukemia variant from hairy cell leukemia: development and validation of diagnostic criteria. Leuk Res. 2013;37:401-409
3. Abdel-Ghafar AA, El Din El Telbany MA, Mahmoud HM, El-Sakhawy YN: Immunophenotyping of chronic B-cell neoplasms: flow cytometry versus immunohistochemistry. Hematol Rep. 2012;4(1):e3