Test Catalog

Test ID: ADV    
Adenovirus Immunostain, Technical Component Only

Useful For Suggests clinical disorders or settings where the test may be helpful

Identification of adenovirus infection

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

For the initial technical component only immunohistochemical (IHC) stain performed, the appropriate bill-only test ID will be reflexed and charged (IHTOI). For each additional technical component only IHC stain performed, an additional bill-only test ID will be reflexed and charged (IHTOA).

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Adenoviruses are 65 to 80 nm, nonenveloped, regular icosahedron pathogens containing double-stranded DNA. Adenovirus infection is often associated with respiratory (HAdV-B and C) and gastrointestinal illness (HAdV-F serotypes 40 and 41) as well as conjunctivitis (HAdV-B and D). Over 51 types of immunologically distinct adenovirus serotypes have been categorized.

Interpretation Provides information to assist in interpretation of the test results

The positive and negative controls are verified as showing appropriate immunoreactivity. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request. Contact 855-516-8404.


Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Age of a cut paraffin section can affect immunoreactivity. Stability thresholds vary widely among published literature and are antigen-dependent. Best practice is for paraffin sections to be cut fresh.

Clinical Reference Recommendations for in-depth reading of a clinical nature

1. Wu E, Nemerow GR: Virus yoga: the role of flexibility in virus host cell recognition. Trends Microbiol 2004;124(4):162-169

2. Ohori NP, Michaels MG, Jaffe R, et al: Adenovirus pneumonia in lung transplant recipients. Hum Pathol 1995;26(10):1073-1079

3. Koneru B, Jaffe R, Esquivel CO, et al: Adenoviral infections in pediatric liver transplant recipients. JAMA 1987;258(4):489-492