Web: | mayocliniclabs.com |
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Email: | mcl@mayo.edu |
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Values are valid only on day of printing. |
Aids in the classification of pituitary adenomas and neoplasms with ectopic hormone production
For the initial technical component only immunohistochemical (IHC) stain performed, the appropriate bill-only test ID will be reflexed and charged (IHTOI). For each additional technical component only IHC stain performed, an additional bill-only test ID will be reflexed and charged (IHTOA).
Adrenocorticotropic hormone (ACTH) is a hormone produced and secreted by corticotrophs in the adenohypophysis (anterior lobe) of the pituitary gland. Normal pituitary exhibits positive staining in a large population of cells (approximately 15% to 20%). Immunohistochemical detection of ACTH may be useful in the classification of pituitary adenomas.
The positive and negative controls are verified as showing appropriate immunoreactivity. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request. Contact 855-516-8404.
Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.
Age of a cut paraffin section can affect immunoreactivity. Stability thresholds vary widely among published literature and are antigen-dependent. Best practice is for paraffin sections to be cut within 6 weeks.
2. Osamura RY, Kajiva H, Takei M, et al: Pathology of the human pituitary adenomas. Histochem Cell Biol 2008;130(3):495-507
3. Scheithauer BW, Jaap AJ, Horvath E, et al: Clinically Silent Corticotroph Tumors of the Pituitary Gland. Neurosurgery 2000;47(3):723-730