Web: | mayocliniclabs.com |
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Email: | mcl@mayo.edu |
Telephone: | 800-533-1710 |
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Values are valid only on day of printing. |
Undetermined metabolic bone disease in wet tissue specimens
Renal osteodystrophy
Osteomalacia
Osteoporosis
Paget disease
Assessing effects of therapy
Identification of some disorders of the hematopoietic system
Aluminum toxicity
Presence of iron in the bone
Hematoxylin and eosin-stained slides are sent to pathology for review. Iron staining or aluminum staining may be performed at an additional charge.
Bone histomorphometry is a very sophisticated procedure utilizing full-thickness bone biopsy.
Techniques such as 2-time interval labeling with tetracycline permit the direct measurement of the rate of bone formation. The information derived is useful in the diagnosis of metabolic bone diseases, including renal osteodystrophy, osteomalacia, and osteoporosis, and other disorders such as aluminum toxicity and iron abnormalities.
The laboratory will provide a quantitative and an interpretive report.
Computer-generated histomorphometric values are given for adequate specimens.
Normal histomorphometric values for iliac crest are provided (female only).
An interpretive report will be provided.
Mineralization or bone formation rates can be done only when tetracycline has been administered on a specific schedule prior to biopsy.
Biopsy site of preference is iliac crest.
Dairy products should not be ingested at the same time as the tetracycline because they interfere with tetracycline uptake.
Recker RR: Bone Histomorphometry: Techniques and Interpretation. Boca Raton, FL, CRC Press, 1983