Web: | mayocliniclabs.com |
---|---|
Email: | mcl@mayo.edu |
Telephone: | 800-533-1710 |
International: | +1 855-379-3115 |
Values are valid only on day of printing. |
Pregabalin (Lyrica) is an anticonvulsant drug used to treat partial seizures in patients and is a more potent successor to gabapentin. Pregabalin is commonly used for neuropathic pain and fibromyalgia. This test can be used by physicians to assess compliance and may be clinically useful in patients with renal failure who generally require lower dosages. Therapeutic and toxic ranges are not well defined. Therapeutic concentrations are reported to be from 2 to 5 mcg/mL, while toxicity may occur at concentrations above 10 mcg/mL.
2.0-5.0 mcg/mL
The serum concentration should be interpreted in the context of the patient's clinical response and other clinical tests. This may provide useful information in patients showing poor response, noncompliance, or adverse effects. Toxicity can occur with concentrations greater or equal to 10 mcg/mL.
This test cannot be performed on whole blood.
1. Baselt R: Disposition of Toxic Drugs and Chemicals in Man. 10th ed. Biomedical Publications; 2014
2. Hiemke C, Bergemann N, Clement HW, et al: Consensus guidelines for therapeutic drug monitoring in neuropsychopharmacology: Update 2017. Pharmacopsychiatry 2018;51:9-62