Test Catalog

Test ID: MEV0    
Methemoglobin Summary Interpretation

Useful For Suggests clinical disorders or settings where the test may be helpful

Incorporating and summarizing subsequent results into an overall evaluation if 1 or more molecular tests are reflexed on the MEV1 / Methemoglobinemia Evaluation

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

This test is an additional consultative interpretation that summarizes all testing as well as any pertinent clinical information, and will be provided after test completion to incorporate subsequent molecular results into an overall evaluation if 1 or more of the following molecular tests are reflexed on the MEV1 / Methemoglobinemia Evaluation:

-ATHAL / Alpha-Globin Gene Analysis, Varies

-WASQR / Alpha-Globin Gene Sequencing, Blood

-WBSQR / Beta-Globin Gene Sequencing, Blood

-WBDDR / Beta-Globin Cluster Locus Deletion/Duplication, Blood

-WGSQR / Gamma-Globin Full Gene Sequencing, Varies


This summary is in addition to interpretations that may be provided for each component.

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Hemoglobin variants can be associated with increased measured levels of methemoglobin and sulfhemoglobin. Some hemoglobin disorders can be very complex and involve abnormalities of the alpha, beta, delta, and gamma genes. These abnormalities can be due to, not only to point alterations, but also deletions within 1 or more globin genes. Multiple genetic variants can be seen in the same patient, and molecular testing is necessary to fully evaluate such cases.


A summary interpretation that incorporates all of the testing performed is beneficial to the ordering physician.

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Only orderable as a reflex. For more information see MEV1 / Methemoglobinemia Evaluation.


An interpretive report will be provided.

Interpretation Provides information to assist in interpretation of the test results

An interpretive report will be provided that summarizes all testing as well as any pertinent clinical information.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

No significant cautionary statements.

Clinical Reference Recommendations for in-depth reading of a clinical nature

1. Beutler E: Methemoglobinemia and sulfhemoglobinemia. In: Beutler E, Lichtman MA, Caller BS, Kipps TJ, eds. Hematology. 5th edition. McGraw-Hill Book Company; 1995:654-663

2. Harteveld CL, Higgs DR: Alpha-thalassemia. Orphanet J Rare Dis. 2010;5:13

3. Thein SL: The molecular basis of beta-thalassemia. Cold Spring Harb Persepct Med. 2013;1;3(5):a011700

4. Crowley MA, Mollan TL, Abdulmalik OY, et al: A hemoglobin variant associated with neonatal cyanosis and anemia. N Engl J Med. 2011;364:1837-1843

5. Harteveld CL, Voskamp A, Phylipsen M, et al: Nine unknown rearrangements in 16p13.3 and 11p15.4 causing alpha- and beta-thalassaemia characterized by high resolution multiplex ligation-dependent probe amplification. J Med Genet. 2005;42:922-931

6. Hein MS, Oliveira JL, Swanson KC, et al: Large deletions involving the beta globin gene complex: genotype-phenotype correlation of 119 cases. Blood. 2015;126:3374