Test Catalog

Test ID: BTB46    
ZBTB46 Immunostain, Technical Component Only

Useful For Suggests clinical disorders or settings where the test may be helpful

Identification of dendritic cells and classification of histiocytic disorders

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Zinc finger and BTB domain-containing protein 46 (ZBTB46) is a transcription factor expressed by classical dendritic cells and committed dendritic cell precursors. Expression of ZBTB46 differentiates histiocytic disorders such as Langerhans cell histiocytosis, histiocytic sarcoma, and indeterminate cell histiocytosis from Rosai-Dorfman and Erdheim-Chester disease.

Interpretation Provides information to assist in interpretation of the test results

This test includes only technical performance of the stain (no pathologist interpretation is performed). If diagnostic consultation by a pathologist is required order PATHC / Pathology Consultation.


The positive and negative controls are verified as showing appropriate immunoreactivity. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request. Contact 855-516-8404.


Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Clinical Reference Recommendations for in-depth reading of a clinical nature

1. Reizis B: Classical dendritic cells as a unique immune cell lineage. J Exp Med 2012 209(6):1053-1056

2. Satpathy AT, Wumesh KC, Albring JC, et al: Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages. J Exp Med 2012 209(6):1135-1152

3. Meredith MM, Liu K, Darrasse-Jeze G, et al: Expression of the zinc finger transcription factor zDC (Zbtb46, Btbd4) defines the classical dendritic cell lineage. J Exp Med 2012 209(6):1156-1165

4. Satpathy AT, Brown RA, Gomulia E, et al: Expression of the transcription factor ZBTB46 distinguishes human histiocytic disorders of classical dendritic cell origin. Mod Path 2018 31:1479-1486