Test Catalog

Test ID: CAMTA    
Calmodulin-Binding Transcription Activator 1 (CAMTA1), Immunostain, Technical Component Only

Useful For Suggests clinical disorders or settings where the test may be helpful

Aids in the diagnosis of epithelioid hemangioendotheliomas

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Calmodulin-binding transcription activator 1 (CAMTA1) protein overexpression in the nucleus is the result of the WWTR1-CAMTA1 gene fusion, which is found in approximately 90% of epithelioid hemangioendotheliomas (EHE). CAMTA1 can be used to distinguish EHE from other tumors with epithelioid morphology.

Interpretation Provides information to assist in interpretation of the test results

The positive and negative controls are verified as showing appropriate immunoreactivity. If a control tissue is not included on the slide, a scanned image of the relevant quality control tissue is available upon request; contact 855-516-8404.


Interpretation of this test should be performed in the context of the patient's clinical history and other diagnostic tests by a qualified pathologist.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

No significant cautionary statements

Clinical Reference Recommendations for in-depth reading of a clinical nature

1. Shibuya R, Matsuyama A, Shiba E, et al:  CAMTA1 is a useful immunohistochemical marker for diagnosing epithelioid haemangioendothelioma. Histopathology 2015; 67:827-835

2. Flucke U, Vogels RJ, de Saint Aubain Somerhausen N, et al: Epithelioid Hemangioendothelioma: clinicopathologic, immunhistochemical, and molecular genetic analysis of 39 cases. Diagn Pathol 2014;9:131 doi: 10.1186/1746-1596-9-131

3. Doyle LA, Fletcher CD, Hornick JL: Nuclear Expression of CAMTA1 Distinguishes Epithelioid Hemangioendothelioma From Histologic Mimics. Am J Surg Pathol 2016;40:94-102