Test Catalog

Test ID: SOLFM    
Soluble Fibrin Monomer, Plasma

Useful For Suggests clinical disorders or settings where the test may be helpful

Assisting in the diagnosis of arterial or venous prethrombotic states in various pathological and clinical situations including disseminated intravascular coagulation (DIC) and postoperative monitoring of surgeries with a high risk of thromboses

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Fibrin monomers are intermediate products formed during the proteolysis of fibrinogen by thrombin. During intravascular coagulation, low levels of thrombin are available in the blood, but the quantity of fibrin monomers formed are not sufficient to aggregate and form a clot; instead, they associate themselves with fibrinogen or fibrinogen-degradation products to form soluble complexes (ie, soluble fibrin monomer complex: SFMC). Intravascular coagulation and fibrinolysis (ICF) or disseminated intravascular coagulation: DIC is a clinical diagnosis; no single test is completely sensitive or specific for ICF.

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Only orderable as part of a coagulation reflex. For more information see:

ALUPP / Lupus Anticoagulant Profile, Plasma

ALBLD / Bleeding Diathesis Profile, Limited, Plasma

AATHR / Thrombophilia Profile, Plasma

APROL / Prolonged Clot Time Profile, Plasma

ADIC / Disseminated Intravascular Coagulation/Intravascular Coagulation and Fibrinolysis (DIC/ICF) Profile, Plasma


< or =8 mcg/mL

Interpretation Provides information to assist in interpretation of the test results

A normal soluble fibrin monomer complex (SFMC) does not exclude the presence of thrombosis or early disseminated intravascular coagulation (DIC)/intravascular coagulation and fibrinolysis (ICF). An elevated SFMC may be seen in patients with venous or arterial thromboembolism or DIC/ICF. It may also be mildly elevated in clotted specimens.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Lipemia can interfere with this assay, causing an underestimation of the soluble fibrin monomer complex (SFMC) level. Therefore, results from lipemic specimens should be interpreted with caution.

Clinical Reference Recommendations for in-depth reading of a clinical nature

1. Dempfle CE: The use of soluble fibrin in evaluating the acute and chronic hypercoagulable state Thrombosis and Haemostasis 1999;82:673

2. Wada H: Increased plasma soluble fibrin monomer levels in patients with disseminated intravascular coagulation American Journal of Hematology 1996;51:255

3. Leko M: Soluble fibrin monomer degradation products as a potential useful marker for hypercoagulable states with accelerated fibrinolysis. Clinica Chimica Acta 2007;386:38