APOLB - Overview: Apolipoprotein B, Serum

Assessment of cardiovascular risk Follow-up studies in individuals with basic lipid measures inconsistent with risk factors or clinical presentation Definitive studies of cardiac risk factors in individuals with significant family...

BILIT - Overview: Bilirubin, Total, Serum

Assessing liver function Evaluating a wide range of diseases affecting the production, uptake, storage, metabolism, or excretion of bilirubin Monitoring the efficacy of neonatal phototherapy

CTSK - Overview: Cathepsin K Immunostain, Technical Component Only

Evaluation for perivascular epithelioid cell neoplasms (PEComas), alveolar soft part sarcoma, and translocation-associated renal cell carcinomas

IODCU - Overview: Iodine/Creatinine Ratio, Random, Urine

Assessment of iodine toxicity or recent iodine exposure using a random urine collection Monitoring iodine excretion rate as index of replacement therapy

BCGR - Overview: Immunoglobulin Gene Rearrangement, Blood

Determining whether a B-cell or plasma cell population is polyclonal or monoclonal using whole blood specimens Identifying neoplastic cells as having B-cell or plasma cell differentiation Monitoring for a persistent neoplasm by...

CRMWS - Overview: Collapsin Response-Mediator Protein-5-IgG, Western Blot, Serum

Evaluation of cases of chorea, vision loss, cranial neuropathy and myelopathy

CDUCR - Overview: Cadmium/Creatinine Ratio, Random, Urine

Detecting exposure to cadmium, a toxic heavy metal, using random urine specimens

CMVM - Overview: Cytomegalovirus (CMV) Antibodies, IgM, Serum

Aiding in the diagnosis of acute infection with cytomegalovirus This test should not be used for screening blood or plasma donors.

HE4 - Overview: Human Epididymis Protein 4, Serum

Aiding in monitoring patients with treated epithelial ovarian cancer for recurrence or progression This test should not be used as a screening test for ovarian cancer.

HERDN - Overview: HER2, Breast, DCIS, Quantitative Immunohistochemistry, Manual No Reflex

Determining overexpression of HER2 protein on formalin-fixed, paraffin-embedded tissue sections in ductal carcinoma in situ or solid/intracystic papillary carcinoma breast tissue This FDA-approved test is most frequently used to evaluate...

GLUTS - Overview: Glutamine Synthetase Immunostain, Technical Component Only

Classification of hepatic adenomas and the identification of focal nodular hyperplasia

CSMRT - Overview: mSMART Plasma Cell Proliferative Disorder, Pre-Analysis Cell Sorting, Bone Marrow

Risk stratification of patients with multiple myeloma, which can assist in determining treatment and management decisions Sorting plasma cells for fluorescence in situ hybridization analysis Risk stratification of patients with newly...

NBILI - Overview: Neonatal Bilirubin, Serum

Assessing liver function Evaluating a wide range of diseases affecting the production, uptake, storage, metabolism, or excretion of bilirubin Monitoring the efficacy of neonatal phototherapy

OCT2 - Overview: OCT-2 Immunostain, Technical Component Only

Classification of lymphomas

PIT1 - Overview: PIT-1 Immunostain, Technical Component Only

Classification of pituitary adenomas

PCTTC - Overview: Purkinje Cell Cytoplasmic Antibody, Type Tr (PCA-Tr) Titer, Spinal Fluid

Serological testing for Purkinje cell cytoplasmic antibody-Tr for patients with acquired cerebellar ataxia of undetermined etiology, particularly if the patient has a history of Hodgkin lymphoma Reporting an end titer result from spinal...

PNP - Overview: Platelet Neutralization Procedure, Plasma

Aiding in the confirmation or exclusion of the presence of a lupus anticoagulant (LAC) inhibitor when used in conjunction with other appropriate coagulation tests. Aids in differentiating deficiencies or inhibitors of specific coagulation...

PCTTS - Overview: Purkinje Cell Cytoplasmic Antibody Type Tr (PCA-Tr) Titer, Serum

Serological testing for Purkinje cell cytoplasmic antibody-Tr for patients with acquired cerebellar ataxia of undetermined etiology, particularly if the patient has a history of Hodgkin lymphoma Reporting an end titer result from serum...

RPTU1 - Overview: Protein/Creatinine Ratio, Random, Urine

Evaluation of renal disease Screening for monoclonal gammopathy

PAX8 - Overview: PAX8 Immunostain, Technical Component Only

Aids in the identification of renal cell carcinomas, as well as papillary thyroid carcinomas and tumors of Mullerian origin

QFEVR - Overview: Q Fever Antibody Screen with Titer Reflex, Serum

Screening for exposure to Coxiella burnetii, the causative agent of Q fever This test should not be used as a screening procedure for the general population.

RIVAR - Overview: Rivaroxaban, Anti-Xa, Plasma

Measuring rivaroxaban concentration in selected clinical situations (eg, kidney insufficiency, assessment of compliance, periprocedural measurement of drug concentration, suspected overdose, advanced age, and extremes of body weight)

P53 - Overview: p53 Immunostain, Technical Component Only

Aiding in the identification of neoplastic cells

P16 - Overview: p16 (INK4a/CDKN2A) Immunostain, Technical Component Only

Aids in the identification of human papilloma virus infection

PIK3T - Overview: PIK3CA Mutation Analysis, Tumor

Identification of hormone receptor positive and human epidermal growth factor receptor 2 negative (HR+/HER2-) advanced breast cancer tumors that may be eligible for treatment with targeted kinase inhibitor therapy (eg, alpelisib).

PTEM - Overview: Platelet Transmission Electron Microscopic Study, Whole Blood

Diagnosing platelet disorders

CUS1 - Overview: Copper, Serum

Diagnosis of: -Wilson disease -Primary biliary cholangitis -Primary sclerosing cholangitis

CDUOE - Overview: Cadmium Occupational Exposure, Random, Urine

Detecting occupational exposure to cadmium, a toxic heavy metal, using random urine specimens

EIACD - Overview: Clostridioides difficile Toxin, EIA, Feces

Diagnosing the presence of toxigenic Clostridioides difficile

CARF - Overview: Carbamazepine, Free, Serum

Monitoring unbound or free carbamazepine levels in patients where the total carbamazepine result is within the therapeutic range, but the patient is experiencing side effects Monitoring carbamazepine (free) therapy in patients who are...

CACR3 - Overview: Calcium/Creatinine Ratio, Random, Urine

Evaluation of calcium oxalate and calcium phosphate kidney stone risk Calculation of urinary supersaturation Evaluation of bone diseases, including osteoporosis and osteomalacia

LALB - Overview: Lysosomal Acid Lipase, Blood

Evaluation of patients with a clinical presentation suggestive of lysosomal acid lipase deficiency using blood specimens This test is not useful to determine carrier status for cholesteryl ester storage disease or Wolman disease.

FMSS2 - Overview: Maternal Serum Screening, Integrated, Specimen #2, Alpha Fetoprotein, Hcg, Estriol, and Inhibin A

Helpful to identify pregnancies at increased risk of having a child with Down syndrome (trisomy 21), Open Neural Tube Defect (ONTD, spina bifida) and trisomy 18 (T18). This test is not diagnostic. The patient information provided with the...

SGSU - Overview: Synthetic Glucocorticoid Screen, Random, Urine

Confirming the presence of the listed synthetic glucocorticoids Confirming the cause of secondary adrenal insufficiency

SSA - Overview: SS-A/Ro Antibodies, IgG, Serum

Evaluating patients at-risk for connective tissue disease with or without interstitial lung disease Detection of both anti-SS-A 52 (Ro52) and SS-A 60 (Ro60) antibodies in serum

TYROS - Overview: Tyrosinase (TYROS) Immunostain, Technical Component Only

Aiding in the identification of normal melanocytes and malignant melanoma

FRT4D - Overview: T4 (Thyroxine), Free, Dialysis, Serum

Determining thyroid status of sick, hospitalized patients Determining thyroid status of patients in whom abnormal binding proteins have been identified Possibly useful in pediatric patients

S100 - Overview: S-100 Immunostain, Technical Component Only

Aids in the identification of various neoplasms

2SC - Overview: S-(2-Succinyl)-Cysteine (2SC) Immunostain, Technical Component Only

Identification of high levels of aberrant S-(2-succino)-cysteine (2SC), secondary to pathogenic alterations of the fumarate hydratase (FH) gene

SCERA - Overview: Saccharomyces cerevisiae Antibody, IgA, Serum

Measuring IgA anti-Saccharomyces cerevisiae antibodies as a part of a profile to aid in distinguishing between ulcerative colitis and Crohn disease in patients for whom the specific diagnosis is unclear based on endoscopic, pathologic, and...

VMAR - Overview: Vanillylmandelic Acid, Random, Urine

Screening children for catecholamine-secreting tumors using a random urine collection when requesting vanillylmandelic acid only Supporting a diagnosis of neuroblastoma Monitoring patients with a treated neuroblastoma

WNMC - Overview: West Nile Virus Antibody, IgM, Spinal Fluid

Aids in diagnosing central nervous system West Nile virus infections during the acute phase

FOL - Overview: Folate, Serum

Investigation of suspected folate deficiency

ALKOT - Overview: Anaplastic Lymphoma Kinase (ALK [OTI1A4]) Immunostain, Technical Component Only

Identification of anaplastic lymphoma kinase expression Diagnosis of inflammatory myofibroblastic tumor and anaplastic large cell lymphoma

HEXAZ - Overview: Tay-Sachs Disease, HEXA Gene, Full Gene Analysis, Varies

Second-tier test for confirming a biochemical diagnosis of Tay-Sachs disease (TSD) Carrier testing of individuals with a family history of TSD but an affected individual is not available for testing or disease-causing mutations have not...

DRPL - Overview: Dentatorubral-Pallidoluysian Atrophy (DRPLA) Gene Analysis, Varies

Confirming the diagnosis of dentatorubral-pallidoluysian atrophy (DRPLA) for symptomatic patients Predictive testing for individuals with a family history of DRPLA and a documented expansion in the ATN1 gene in an affected family member

MAGRU - Overview: Magnesium/Creatinine Ratio, Random, Urine

Assessing the cause of abnormal serum magnesium concentrations Determining whether nutritional magnesium loads are adequate Calculating urinary calcium oxalate and calcium phosphate supersaturation and assessing kidney stone risk.

12PU1 - Overview: Protein, Total, 12 Hour, Urine

Evaluation of renal disease Screening for monoclonal gammopathy Screening for postural (orthostatic) proteinuria In select clinical situations, collection of a 12-hour specimen may allow more rapid detection of proteinuria states (eg,...

OROT - Overview: Orotic Acid, Random, Urine

Evaluation of the differential diagnosis of hyperammonemia and hereditary orotic aciduria Sensitive indicator of ornithine transcarbamylase (OTC) activity after administration of allopurinol or a protein load to identify OTC carriers

GUS - Overview: Guselkumab, Serum

Assessing the response to guselkumab therapy Assessing the need for dose escalation Evaluating the potential for dose de-escalation or discontinuation of therapy Monitoring patients who need to be above a certain guselkumab...