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New tests launched in April - Insights

In April 2022, Mayo Clinic Laboratories announced fourteen new tests along with numerous reference value changes, obsolete tests, and algorithm changes.

Thrombotic microangiopathy (TMA) - Insights

View our comprehensive testing suite designed to confirm diagnosis and facilitate treatment of thrombotic microangiopathy.

Lyme Neuroborreliosis - Insights

In this month’s “Hot Topic,” Elitza Theel, Ph.D., will discuss diagnostic testing options for patients with suspected neuroinvasive Lyme disease or Lyme neuroborreliosis.

newborn-screen-follow-up-elevated-c5-dc.pdf

© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. Reviewed 05/2025 Newborn screen result: Elevated glutarylcarnitine (C5-DC) Perform: Plasma ammonia, blood gas, glucose, electrolytes Order: ■ OAU / Organic...

Autoimmune Encephalopathy Testing - Mayo Clinic Laboratories

Our phenotype specific testing for autoimmune encephalopathy contains only clinically relevant antibodies providing accurate answers for treatment guidance.

ganglioside_antibody_panel_algorithm.pdf

08/2024© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. Ganglioside Antibody Panel Algorithm IgG Monosialo GM1 titer is performed IgM Monosialo GM1 titer is performed IgG Disialo GD1b titer is...

newborn-screen-elevated-c16-c18-acylcarnitine.pdf

© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. 08/2023 Newborn screen result: ■ Elevated C16 acylcarnitine ■ Possible elevated 18:1 acylcarnitine Perform: Plasma ammonia, blood gas, glucose, electrolytes,...

newborn-screen-decreased-free-carnitineco.pdf

© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. 07/2025 Newborn screen result: ■ Decreased free carnitine (C0) Perform: Plasma ammonia, blood gas, glucose, electrolytes, creatine kinase, liver function...

newborn-screen-follow-up-elevated-c14-long-chain-acylcarnitine.pdf

© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. 06/2023 Newborn screen result: Elevated C14:1 with possible elevations of other long-chain acylcarnitine Perform: Plasma ammonia, blood gas, glucose,...

celiac_disease_gluten-free_cascade_test_algorithm.pdf

05/2022© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. STOP No further testing required Celiac Disease Gluten-Free Cascade Test Algorithm Patient following a gluten-free diet with uncertain or...

newborn-screen-elevated-c8-acylcarnitine-lesser-elevations-c6-c10-acylcarnitines.pdf

© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. 08/2023 Newborn screen results: ■ Elevated C8 acylcarnitine ■ Lesser elevations of C6 and C10 acylcarnitines Perform: Glucose, electrolytes, blood gas, liver...

Mayo Clinic Laboratory and Pathology Research Roundup: Aug. 7 - Insights

This week’s Research Roundup highlights a randomized controlled trial of postoperative belladonna and opium rectal suppositories in vaginal surgery.

Assay monitors response to monoclonal antibody therapy: Maria Alice Willrich, Ph.D. - Insights

Maria Alice Willrich, Ph.D., explains how Mayo Clinic Laboratories' new assay provides therapeutic drug monitoring of risankizumab, or RISA. Test results help guide care for patients with plaque psoriasis, psoriatic arthritis, and Crohn's...

Panel offers proactive drug monitoring for IBD: Maria Willrich, Ph.D., and Melissa Snyder, Ph.D. - Insights

Maria Willrich, Ph.D., and Melissa Snyder, Ph.D., describe Mayo Clinic Laboratories' panel for proactive therapeutic drug monitoring of patients with inflammatory bowel disease. The panel expands options for clinicians assessing patients'...

MAG Antibody Testing [Test in Focus] - Insights

John Mills, Ph.D., explains Mayo Clinic Laboratories’ approach to MAG antibody testing. The ELISA-based assay uses higher reference ranges and human MAG antigen to detect MAG antibodies, which are associated with a rare, hard-to-treat...

Autoimmune Myelopathy Testing - Mayo Clinic Laboratories

Mayo Clinic Laboratories is the only laboratory in the world to offer testing for a novel form of autoimmune meningoencephalomyelitis.

demyelinating-neuropathy-evaluation-algorithm.pdf

08/2024© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. Demyelinating Neuropathy Evaluation Algorithm Neurofascin-155 IgG4 IgG Monosialo GM1 titer is performed IgM Monosialo GM1 titer is performed IgG...

newborn-screen-follow-up-elevated-c4-c5-acylcarnitine-elevated-acylcarnitines.pdf

© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. 09/2023 Newborn screen result: ■ Elevated C4 ■ Elevated C5 ■ Possible other acylcarnitine elevations Perform: Plasma ammonia, blood gas, glucose,...

newborn-screen-elevated-c16-oh-c18-oh.pdf

© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. 08/2023 Newborn screen result: ■ Elevated C16-OH acylcarnitine ■ Possible elevated C18-OH acylcarnitine Perform: Glucose, electrolytes, blood gas, lactate,...

Allergens - Insights

Browse our menu of immunoglobulin E (IgE) antibody testing, which can be useful in the evaluation of patients suspected of having an allergic disease.

Amino acid disorders - Insights

Learn more about how amino acid metabolism testing at Mayo Clinic Laboratories can assist in diagnosing the most preventable and treatable amino acid disorders.

Mayo Clinic Laboratory and Pathology Research Roundup: Dec. 10 - Insights

This week’s Research Roundup highlights the evaluation of monoclonal gammopathy of renal significance: A consensus report of the International Kidney and Monoclonal Gammopathy Research Group.

Peroxisomal biogenesis and metabolism - Insights

Learn more about how Mayo Clinic Laboratories’ testing for peroxisomal biogenesis and metabolism disorders can assist in the identification of these sometimes fatal conditions.

Mayo Clinic Laboratory and Pathology Research Roundup: Nov. 26 - Insights

This week’s Research Roundup highlights the effect of inorganic nitrite versus a placebo on exercise capacity among patients with heart failure with preserved ejection fraction.

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Mayo Clinic Laboratory and Pathology Research Roundup: Oct. 15 - Insights

This week’s Research Roundup highlights paraneoplastic neuronal intermediate filament autoimmunity.

December 2022 - Renal - Insights

This "Pathways" program provides an Anatomic Pathology case that includes a history, potential answers, rationale, and relevant references. This case sub-specialty is Renal Pathology.

Autoimmune Movement Disorders - Mayo Clinic Laboratories

Our phenotype specific testing for autoimmune movement disorders contain clinically relevant antibodies providing accurate answers for treatment guidance.

Specimen Collection and Preparation - Mayo Clinic Laboratories

Test Catalog AlgorithmsDownload Test Catalog & Interpretive HandbookNew TestsNY State Informed Consent TestsPerforming LocationsReferred TestsSpecialty TestingTest Updates...

Thermo Fisher Scientific: Illuminating rare cancer prognosis and improving patients' lives - Insights

Aiming to advance understanding of hard-to-predict gastroenteropancreatic neuroendocrine tumors (GEP-NETs), Thermo Fisher Scientific joined forces with Mayo Clinic and BioPharma Diagnostics to validate and gain U.S. regulatory clearance of...

Emergency/Overdose - Mayo Clinic Laboratories

Emergency/Overdose This test is intended to manage an apparent overdose, intoxicated patient, or determine if a specific set of symptoms might be due to the presence of drugs. This test is designed...

Malabsorption - Mayo Clinic Laboratories

Stool testing is a critical component of diagnosing EPI and Mayo Clinic Laboratories offers multiple tests to help clinicians in their work-up of these patients.

Mayo Clinic Laboratory and Pathology Research Roundup: Nov. 5 - Insights

This week’s Research Roundup highlights gastrointestinal and extra-intestinal manifestations of IgG4-related disease.

autoimmune-paraneoplastic-gastrointestinal-dysmotility-evaluation-algorithm.pdf

© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. 05/2024 Autoimmune/Paraneoplastic Gastrointestinal Dysmotility Evaluation Algorithm ■ PCA-2 IFA titer■ ANNA-1 antibody by immunoblot ■ ANNA-2 antibody...

autoimmune-paraneoplastic-dysautonomia-evaluation-algorithm.pdf

© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. Autoimmune/Paraneoplastic Dysautonomia Evaluation Algorithm 05/2024 ■ AP3B2 antibody by CBA ■ AP3B2 antibody by IF titer assay ■ PCA-2 IFA titer■ ANNA-1...

IMPACTS Team Continues to Combat Life-Threatening Arthropod-Borne Infections in Belize - Insights

Now in its second year of a five-year initiative to better understand and detect arboviruses in Belize, the IMPACTS (Integrated Mayo Clinic Program for Arbovirus Community health education Training and Surveillance) project has expanded its...

Inflammatory Bowel Disease: IBDP2 - Insights

In this test specific episode of the  "Answers From the Lab" podcast, Melissa Snyder, Ph.D., explains how IBDP2, when used after first-line testing has failed, can distinguish between ulcerative colitis and Crohn’s disease.

myeloproliferative_neoplasm_a_diagnostic_approach_to_peripheral_blood_evaluation.pdf

05/2023© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. *A minor criterion for PV **In the appropriate clinicopathologic setting Myeloproliferative Neoplasm: A Diagnostic Approach to Peripheral Blood...

Mitochondrial disease - Insights

Learn about our four molecular testing options, which can be used to confirm a diagnosis and identify a specific mitochondrial syndrome.

Myasthenia Gravis Testing - Mayo Clinic Laboratories

Our diagnostic algorithms consist of tests that are always performed, and then additional testing is performed depending on the initial results.

Mayo Clinic Laboratories offers first test to detect recently discovered autoimmune disease associated with testicular cancer - Insights

Mayo Clinic Laboratories has launched a first-in-the-U.S. autoimmune test of the Kelchlike protein 11 antibody, or KLHL11, which is used to detect autoimmune disease associated with testicular cancer.

MCL Blood Spot Collections Instructions Flyer MC4091135

MCL Blood Spot Collections Instructions Flyer Blood Spot Collection Instructions Instructions Blood Collection Heelstick Fingerstick minutes place warmer

NY State Informed Consent Tests - Mayo Clinic Laboratories

NY State Informed Consent Tests New York State clients are required by New York State regulations to have completed informed-consent forms on file. When ordering the following tests, all NYS clients are required to indicate to...

NY State Informed Consent Tests - Mayo Clinic Laboratories

Test Catalog AlgorithmsDownload Test Catalog & Interpretive HandbookNew TestsNY State Informed Consent TestsPerforming LocationsReferred TestsSpecialty TestingTest Updates...

New tests launched in November - Insights

In November 2021, Mayo Clinic Laboratories announced thirty four new tests along with numerous reference value changes, obsolete tests, and algorithm changes.

Autoimmune Axonal Evaluation - Insights

Div Dubey, M.B.B.S., explains Mayo Clinic Laboratories' phenotypic testing approach for autoimmune axonal neuropathy. The comprehensive, serologic panel detects for antibodies with clinical relevance to the disease to provide clarity on...

parasitic_investigation_of_stool_specimens_algorithm.pdf

© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. 06/2023 Parasitic Investigation of Stool Specimens Algorithm Patients with watery diarrhea Risk factors for parasitic infection include: ■ AIDS ■ ≤5 years...

IgA-mediated autoimmune bullous dermatoses - Insights

In this month’s “Hot Topic,” Julia Lehman, M.D., will discuss autoimmune bullous dermatoses, the rare category of blistering skin diseases that are caused by the development of autoantibodies against various constitutive parts of the...

Autoimmune Encephalitis Misdiagnosis - Insights

In this month's "Hot Topic," Eoin Flanagan, M.B., B. Ch., discusses the important issue of autoimmune encephalitis misdiagnosis and identifies red flags that be useful in clinical practice to suggest alternative diagnoses and highlight...

https://news.mayocliniclabs.com/mc2775-782/

FO U R RE AL -W O RL D C O LL AB O RA TI VE E XA M PL ES to Mayo Clinic diagnostics C O N N E C T I N G Pharma and biotech TABLE OF CONTENTS What makes a good testing partner? Case study 1 Gastrointestinal study collects and tests...