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Osmotic fragility testing - Insights
In this month’s “Hot Topic,” James Hoyer, M.D., discusses the importance of using a control tube during osmotic fragility testing.
Orexin-A/Hypocretin-1 for the Diagnosis of Type 1 Narcolepsy [Test in Focus] - Insights
The standard test for the diagnosis of narcolepsy is the multiple sleep latency test (MSLT). The MSLT is a complex test to perform as well as to interpret. The orexin-A/hypocretin-1 test is a sensitive and specific alternative to the MSLT...
Sleep Review explores orexin testing for narcolepsy with Joshua Bornhorst, Ph.D. - Insights
Dr. Bornhorst explains orexin testing's role in diagnosing type 1 narcolepsy and the significance of its availability through Mayo Clinic Laboratories.
Comprehensive neuromuscular panel - Insights
Find out how the emergence of advanced molecular testing technologies has enhanced the detection of inherited neuromuscular disorders.
Additional neuromuscular disorders - Insights
Learn how our comprehensive menu of focused panels can provide clarity and confidence when diagnosing neuromuscular disorders.
Learn how our muscular dystrophy genetic testing can help patients access variant-specific therapies and determine eligibility for clinical trials.
Mitochondrial Disease [Test in Focus] - Insights
Linda Hasadsri, M.D., Ph.D., explains how Mayo Clinic Laboratories’ inclusive approach to mitochondrial disease testing expedites diagnosis. Using innovative methodologies like custom reagents and droplet digital PCR enables precision...
Molecular Mitochondrial Testing [Test in Focus] - Insights
The diagnosis of mitochondrial disease can be particularly challenging as the presentation can occur at any age, involve virtually any organ system, and be associated with widely varying severities. Due to the considerable overlap in the...
Unique pediatric evaluation targets relevant autoimmune/CNS antibodies - Insights
Andrew McKeon, M.B., B.Ch., M.D., explains how Mayo Clinic Laboratories' pediatric autoimmune/CNS testing can better guide the treatment of autoimmune neurological diseases in children. The tailored evaluation covers only biomarkers...
Forensic Pathology 101 - Insights
In this episode of Lab Medicine Rounds, Reade Quinton, M.D., discusses what it takes to become a forensic pathologist, talks about common misconceptions related to the field, and describes what a day in the life of a forensic pathologist is...
Quality in the clinical practice - Insights
In this episode, Paula Santrach, M.D., associate professor of laboratory medicine and pathology and consultant in Transfusion Medicine at Mayo Clinic, discusses cultivating quality in the clinical practice.
Genetic Testing for Inherited Cardiovascular Disorders - Insights
In this month's "Hot Topic," Linnea Baudhuin, Ph.D., discusses Mayo Clinic Laboratories’ up-to-date gene panel tests for cardiomyopathies and arrhythmias, connective tissue and vascular fragility disorders, dyslipidemias, and congenital...
Mayo Clinic Laboratory and Pathology Research Roundup: February 20 - Insights
This week's research roundup feature: Patients with dementia with Lewy bodies (DLB) may have Alzheimers disease (AD) pathology that can be detected by plasma biomarkers. Our objective was to evaluate plasma biomarkers of AD and their...
Mayo Clinic Laboratory and Pathology Research Roundup: February 13 - Insights
This week's research roundup feature: VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome, caused by somatic mutations in UBA1, is an autoinflammatory disorder with diverse systemic manifestations. Thrombosis is a...
Mayo Clinic Laboratory and Pathology Research Roundup: February 27 - Insights
This week's research roundup feature: Both targeted therapies and immunotherapies provide benefit in resected Stage III melanoma. We hypothesized that the combination of targeted and immunotherapy given prior to therapeutic lymph node...
Mayo Clinic Laboratory and Pathology Research Roundup: January 30 - Insights
This week's research roundup feature: Incapacitated regulatory T cells (Tregs) contribute to immune-mediated diseases. Inflammatory Tregs are evident during human inflammatory bowel disease (IBD); however, mechanisms driving the development...
Mayo Clinic Laboratory and Pathology Research Roundup: December 26 - Insights
This week's research roundup feature: Histoplasma and Blastomyces antigen detection assays are commonly used diagnostic tools. However, a high level of cross-reactivity between these antigens prevents definitive pathogen identification by...
Mayo Clinic Laboratory and Pathology Research Roundup: January 2 - Insights
This week's research roundup feature: Sarcomas are a recently identified group of undifferentiated round/spindle cell neoplasms with a predilection for the head and neck region.
Mayo Clinic Laboratory and Pathology Research Roundup: December 12 - Insights
This week's research roundup feature: Most patients with solitary bone plasmacytomas (SBP) progress to multiple myeloma (MM) after definitive radiation therapy as their primary treatment. Whether the presence of high-risk (HR) cytogenetic...
Mayo Clinic Laboratory and Pathology Research Roundup: January 9 - Insights
This week's research roundup feature: To describe a 41-year-old woman with a history of neonatal onset multisystem inflammatory disease, on treatment with daily subcutaneous injections of 600 mg of recombinant interleukin-1 receptor...
Mayo Clinic Laboratory and Pathology Research Roundup: February 6 - Insights
This week's research roundup feature: Powassan virus (POWV) is an emerging arthropod-borne flavivirus, transmitted by Ixodes spp. ticks, which has been associated with neuroinvasive disease and poor outcomes.
Mayo Clinic Laboratory and Pathology Research Roundup: January 23 - Insights
This week's research roundup feature: Measles virus (MV) vaccine strains have shown significant preclinical antitumor activity against glioblastoma (GBM), the most lethal glioma histology. In this first in human trial (NCT00390299), a...
Mayo Clinic Laboratory and Pathology Research Roundup: December 19 - Insights
This week's research roundup feature: R0 resection and radiation therapy have been associated with improved overall survival (OS) in patients with thymic carcinoma (TC). Here, we analyzed which subgroups of patients derive the greatest...
Mayo Clinic Laboratory and Pathology Research Roundup: January 16 - Insights
This week's research roundup feature: Understanding the incidence, causes, and trends of sudden cardiac death (SCD) among young competitive athletes is critical to inform preventive policies.
Mayo Clinic Classical Hematology Conference - Insights
This conference will provide reviews and updates about the laboratory and clinical aspects of nonmalignant hematology and bleeding and thrombotic disorders. Combining the clinical and laboratory experience of Mayo Clinic faculty, we will...
Mayo Clinic Classical Hematology Conference - Insights
This conference will provide reviews and updates about the laboratory and clinical aspects of nonmalignant hematology and bleeding and thrombotic disorders. Combining the clinical and laboratory experience of Mayo Clinic faculty, we will...
West Nile virus: Elitza Theel, Ph.D. - Insights
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic, and Elitza Theel, Ph.D., director of the Infectious Diseases Serology Laboratory at Mayo Clinic,...
Protecting Against Winter Respiratory Viruses: Bill Morice, M.D., Ph.D. - Insights
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic, is joined by William Morice II, M.D., Ph.D., CEO and president of Mayo Clinic Laboratories, to...
Evolution of Syphilis: Elitza Theel, Ph.D. - Insights
In this episode of “Answers From the Lab,” host Bobbi Pritt, M.D., chair of the Division of Clinical Microbiology at Mayo Clinic, is joined by Elitza Theel, Ph.D., director of the Infectious Diseases Serology Laboratory at Mayo Clinic, to...
Antimicrobial Crisis: A Silent Threat Claiming Lives - Insights from Dr. Robin Patel - Insights
Globally, five million deaths are associated with bacterial antimicrobial resistance each year, but the complexity of the issue is there is no single solution because we need to use antibiotics. It’s about finding a different way to live...
Alpha-gal testing [Test in Focus] - Insights
Joshua Bornhorst, Ph.D., associate director of Mayo Clinic's Clinical Immunoassay Lab, explains how humans can develop an allergy to the alpha-gal molecule, and he describes a new allergen antibody test that can be used to detect it. Dr....
Mayo Clinic Research Advances Diagnostics to Lead COVID-19 Pandemic Response - Insights
When COVID-19 spread across the U.S. in early March, Mayo Clinic’s Advanced Diagnostic Laboratory urgently responded.
Elitza Theel, Ph.D., Featured in the Star Tribune - Insights
Dr. Theel, director, Mayo Clinic Infectious Diseases Serology Laboratory, was recently highlighted in the Star Tribune's special issue featuring heroes of the pandemic.
Inflammatory Bowel Disease: IBDP2 - Insights
In this test specific episode of the "Answers From the Lab" podcast, Melissa Snyder, Ph.D., explains how IBDP2, when used after first-line testing has failed, can distinguish between ulcerative colitis and Crohn’s disease.
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Mayo Clinic Classical Hematology Conference - Insights
This conference will provide reviews and updates about the laboratory and clinical aspects of nonmalignant hematology and bleeding and thrombotic disorders. Combining the clinical and laboratory experience of Mayo Clinic faculty, we will...
Mayo Clinic Classical Hematology Conference - Insights
This conference will provide reviews and updates about the laboratory and clinical aspects of nonmalignant hematology and bleeding and thrombotic disorders. Combining the clinical and laboratory experience of Mayo Clinic faculty, we will...
Mayo Clinic Classical Hematology Conference - Insights
This conference will provide reviews and updates about the laboratory and clinical aspects of nonmalignant hematology and bleeding and thrombotic disorders. Combining the clinical and laboratory experience of Mayo Clinic faculty, we will...
Mayo Clinic Classical Hematology Conference - Insights
This conference will provide reviews and updates about the laboratory and clinical aspects of nonmalignant hematology and bleeding and thrombotic disorders. Combining the clinical and laboratory experience of Mayo Clinic faculty, we will...
Mayo Clinic Classical Hematology Conference - Insights
This conference will provide reviews and updates about the laboratory and clinical aspects of nonmalignant hematology and bleeding and thrombotic disorders. Combining the clinical and laboratory experience of Mayo Clinic faculty, we will...
Mayo Clinic Classical Hematology Conference - Insights
This conference will provide reviews and updates about the laboratory and clinical aspects of nonmalignant hematology and bleeding and thrombotic disorders. Combining the clinical and laboratory experience of Mayo Clinic faculty, we will...
Improving diagnosis of rare congenital disorders - Insights
Experts at Mayo Clinic have developed a unique method of testing that combines new technology with novel bioinformatics to promptly detect a group of uncommon genetic conditions that are often difficult to identify.
Epic journey yields unique offering - Insights
The quest to create a test pinpointing the source of the rare, testicular cancer-associated illness successfully concluded in the summer of 2021.
An inside look at the state-of-the-art supports enabling invention - Insights
A web of innovation within Mayo Clinic Laboratories links research and test development with clinical practice, enabling for some of the world’s most pioneering methodologies. Underpinning this innovation network are unique supports that...
Patient-focused pragmatism: The Mayo Clinic innovation model - Insights
In a world of ever-faster technical change, Mayo Clinic Laboratories is uniquely positioned to innovate. Collaboration with clinicians pinpoints unmet patient needs and facilitates the development of diagnostic testing that provides...
Mass spectrometry-based assay detects viral antigens directly from clinical specimens - Insights
In a newly published study, a team from Mayo Clinic’s Advanced Diagnostics Laboratory has developed a mass spectrometry-based assay that’s able to detect COVID-19 (SARS-CoV-2) pathogens from human proteins with, remarkably, 98% sensitivity...
Using metal detectors to ward off wayward specimens - Insights
To safeguard patient samples, staff in Mayo Clinic’s Histology Laboratory devised an inventive way to ensure that none of the paraffin-embedded blocks processed in the lab ever ends up in the trash.