Neuroimmunology: Updates and antibody test utilization - Insights
In this month’s “Hot Topic,” Andrew McKeon, M.B., B.Ch., M.D., reviews the use of neurological phenotype-based evaluations, the move away from the paraneoplastic evaluation, and upcoming changes to test profiles.
Diagnostic Testing Algorithms for Celiac Disease - Insights
In this month's "Hot Topic," Melissa Snyder, Ph.D., co-director of the antibody immunology laboratory at Mayo Clinic, discusses celiac disease and the role of diagnostic testing algorithms.
IMPACTS Team Continues to Combat Life-Threatening Arthropod-Borne Infections in Belize - Insights
Now in its second year of a five-year initiative to better understand and detect arboviruses in Belize, the IMPACTS (Integrated Mayo Clinic Program for Arbovirus Community health education Training and Surveillance) project has expanded its...
Raising the Bar on Newborn Screening Test Performance - Insights
Newborn screening panels that test for a variety of conditions are available in every state; however, test performance and response rate by each state are very different. Mayo Clinic's Biochemical Genetics Laboratory created the...
Gadolinium-based contrast agents (GBCAs) have revolutionized MRIs by increasing the clinical utility and detection sensitivity of these exams. GBCAs also contain gadolinium, a rare earth metal with unique chemical properties. This article...
In the fall of 2017, Shayla Polanchek, a recent recipient of a heart transplant at Mayo Clinic in Rochester, Minnesota, returned to campus to review the specimen of her old heart, the one that had been removed from her chest. She had asked...
Multicenter Collaboration Defends against Vector-Borne Diseases - Insights
Teamwork is critical among staff from Mayo Clinic, the Centers for Disease Control and Prevention, Minnesota Department of Health, and the University of Wisconsin-Madison in order to keep tabs on tick trends and defend against vector-borne...
Surprises in Coagulation Testing - Insights
In this “Hot Topic,” William Nichols, M.D., presents a case study that demonstrates how pre- and postanalytic variables of the patient and blood samples can have confounding effects on the laboratory evaluation of coagulation disorders.
NGS for Myeloid Neoplasm Evaluation - Insights
In this month's "Hot Topic," David Viswanatha, M.D., discusses updates to Mayo Clinic's next-generation sequencing (NGS) for myeloid neoplasm evaluation, involving new test targets, the rationale for new genetic regions, alignments with the...
In this month’s “Hot Topic,” Robin Patel, M.D., discusses how matrix-assisted laser desorption ionization time of flight (MALDI TOF) mass spectrometry works for bacterial identification, including the strengths and limitations of this...
Cardiovascular Biomarkers of Atherosclerotic Risk - Insights
In this month’s “Hot Topic,” Vlad Vasile, M.D., Ph.D., reviews ceramides and their atherosclerotic risk through defining ceramides, talking about when they should be tested for and touch on the topic of ceramides in primary prevention.
Top Gun Phlebotomy - Butterfly Use: The Good, the Bad, and the Ugly - Insights
In this month’s “Hot Topic,” Brad Karon, M.D., Ph.D., will discuss recent information on the advantages and disadvantages of using butterfly needles for blood collection.
Optic Neuritis in the Era of Biomarkers - Insights
Antibodies to aquaporin-4 and myelin oligodendrocyte glycoprotein (MOG) are recently described biomarkers seen in a subset of atypical optic neuritis which have revolutionized our understanding of the condition. In this “Hot Topic,” my...
PD-L1 Testing by Immunohistochemistry - Insights
In this month's "Hot Topic," Anja Roden, M.D., discusses the role of PD-L1 interaction in the immune system, challenges of PD-L1 testing, and current PD-L1 companion testing in various tumor types.
Congenital disorders of glycosylation - Insights
In this month’s “Hot Topic,” Gessi Pino, a genetic counselor in the Biochemical Genetics Lab at Mayo Clinic, and Kimiyo Raymond, M.D., a clinical consultant in the laboratory and an expert in Congenital Disorders of Glycosylation (CDG),...
Our Mayo Clinic colleagues are in San Diego for the 60th American Society of Hematology Annual Meeting and Exhibition. Follow this blog for live updates from #ASH18 as we attend the conference, mingle with colleagues at booth #2927, and...
Autoimmune Encephalopathy Testing - Mayo Clinic Laboratories
Our phenotype specific testing for autoimmune encephalopathy contains only clinically relevant antibodies providing accurate answers for treatment guidance.
New tests launched in November - Insights
In November 2021, Mayo Clinic Laboratories announced thirty four new tests along with numerous reference value changes, obsolete tests, and algorithm changes.
Behind the scenes in neural antibody testing - Insights
In this month’s “Hot Topic,” John Mills, Ph.D., explains the central role of tissue immunofluorescence in the identification of neural antibodies and discusses the benefits of an integrated laboratory approach to the development and...
Selecting Pathology Specimens for Solid Tumors Next-Generation Sequencing - Insights
In this month’s “Hot Topic,” Sounak Gupta, M.B.B.S., Ph.D., discusses selecting tissues and other tissue considerations for molecular testing. He also reviews tissue metrics and requirements, which differ based on test platforms. It is...
Diagnostic Testing Algorithms for Celiac Disease - Insights
In this month’s “Hot Topic,” Melissa Snyder, Ph.D., will review the diagnostic testing algorithms for celiac disease and highlight the advantages and limitations of certain tests, including serology and genetic assays.
The diagnosis of Myeloproliferative Neoplasm (MPN) must include an integrated approach and combine the clinical findings with laboratory results. In our latest “Hot Topic,” Rong He, M.D., discusses the subclassification of MPNs and the use...
Helicobacter pylori Infection: Serologic Testing Not Recommended [Communiqué] - Insights
Helicobacter pylori (H pylori) infection is among the most common bacterial infections worldwide with approximately one-half of the world’s population infected. Several invasive and noninvasive testing methods are available to detect H...
Chromogenic Factor VIII and IX Assays: Impact on Diagnosis and Management of Hemophilia - Insights
In this month’s “Hot Topic,” Rajiv Pruthi, M.B.B.S., will discuss different types of hemophilia along with their pathologic basis. He will also cover various types of factor assays such as one stage and chromogenic factor assays for...
Infective Endocarditis - Insights
In this month’s “Hot Topic,” Robin Patel, M.D., will review the laboratory methods used to diagnose infectious endocarditis. Specifically, she’ll discuss the role of blood cultures, nucleic acid amplification tests, histopathology, and...
Pathways Case Studies: July 2020 - Insights
This "Pathways" program provides Anatomic and Clinical Pathology cases that include a history, potential answers, rationale, and relevant references. Cases for July include the following sub-specialties: Bone and Soft Tissue & Pulmonary,...
Updated Test Promises Fewer False Positives in Newborn Screening for Krabbe Disease - Insights
Mayo Clinic’s Biochemical Genetics Laboratory has announced an updated second-tier test to detect Krabbe disease (KD) that uses psychosine (PSY) as a disease marker. The new test method has significantly higher sensitivity to detect this...
Update on 2021 WHO classification of lung tumors - Insights
In this month’s “Hot Topic,” Anja Roden, M.D., discusses new entities and changes of terminology in the 2021 World Health Organization (WHO) classification of lung tumors as well as the nomenclature in small biopsies.
In this “Hot Topic,” Elitza Theel, Ph.D., discusses how common cases of presumed Lyme disease go unreported each year and discusses scenarios in which testing for Lyme disease is indicated and reviews both recommended and inappropriate...
Pathways Case Studies: March 2021 - Insights
This "Pathways" program provides Anatomic and Clinical Pathology cases that include a history, potential answers, rationale, and relevant references. Cases for March include the following sub-specialties: Pulmonary Pathology, Cardiovascular...
Pathways Case Studies: February 2021 - Insights
This "Pathways" program provides Anatomic and Clinical Pathology cases that include a history, potential answers, rationale, and relevant references. Cases for February include the following sub-specialties: Neuropathology,...
Pathways Case Studies: April 2021 - Insights
This "Pathways" program provides Anatomic and Clinical Pathology cases that include a history, potential answers, rationale, and relevant references. Cases for April include the following sub-specialties: Genitourinary Pathology,...
Membranoproliferative glomerulonephritis (MPGN) is a pattern of glomerular injury. Based on the etiology of MPGN, Drs. Sethi and Fervenza proposed a new histologic classification of MPGN into Ig/IC-mediated MPGN and complement-mediated...
Phlebotomy Top Gun: Order of Draw-Do We Still Care? - Insights
In this month’s “Hot Topic,” Brad Karon, M.D., Ph.D., will cover the need and evidence behind following the order of draw recommendations for routine blood collection. Specifically, does evidence demonstrate a need to collect serum tubes...
ACHE 2017 Congress on Healthcare Leadership Live Blog - Insights
Andy Cousin, FACHE, Director of Product Management and Marketing for Mayo Medical Laboratories, is attending this year's ACHE Congress on Health Care Leadership conference in Chicago. He will be sharing his thoughts and photos from the...
Pleural Mesothelioma - Insights
In this month's "Hot Topic," Anja Roden, M.D., a thoracic pathologist at Mayo Clinic, gives an update on the 2021 World Health Organization (WHO) classification and ancillary testing of pleural mesothelioma.
Pathways Case Studies: October 2022 - Insights
This "Pathways" program provides Anatomic and Clinical Pathology cases that include a history, potential answers, rationale, and relevant references. Cases for October include the following sub-specialties: Cardiovascular Pathology,...
Pediatric neuro-oncology informative cases - Insights
Neuro-oncology is a complex field undergoing rapid changes with the advancement and evolution of sophisticated genetic testing. Evidence continues to grow in support of broad molecular and cytogenetic analysis for patients with brain...
CPT codes and LOINC update: November 2020 - Insights
The following list includes updates posted to mayocliniclabs.com during the month of November
Membranoproliferative glomerulonephritis (MPGN) is a pattern of glomerular injury. Based on the etiology of MPGN, Drs. Sethi and Fervenza proposed a new histologic classification of MPGN into Ig/IC-mediated MPGN and complement-mediated...
Pathways Case Studies: March 2022 - Insights
This "Pathways" program provides Anatomic and Clinical Pathology cases that include a history, potential answers, rationale, and relevant references. Cases for March include the following sub-specialties: Breast Pathology, Cardiovascular...
The Region 4 Stork (R4S) Collaborative Project - Insights
This is a 6-part series describing the products and clinical tools of a laboratory quality improvement project called Region 4 Stork, or R4S.
The Region 4 Stork (R4S) Collaborative Project - Insights
This is a 6-part series describing the products and clinical tools of a laboratory quality improvement project called Region 4 Stork, or R4S.
The Region 4 Stork (R4S) Collaborative Project - Insights
This is a 6-part series describing the products and clinical tools of a laboratory quality improvement project called Region 4 Stork, or R4S.
The Region 4 Stork (R4S) Collaborative Project - Insights
This is a 6-part series describing the products and clinical tools of a laboratory quality improvement project called Region 4 Stork, or R4S.
The Region 4 Stork (R4S) Collaborative Project - Insights
This is a 6-part series describing the products and clinical tools of a laboratory quality improvement project called Region 4 Stork, or R4S.
The Region 4 Stork (R4S) Collaborative Project - Insights
This is a 6-part series describing the products and clinical tools of a laboratory quality improvement project called Region 4 Stork, or R4S.
The Region 4 Stork (R4S) Collaborative Project - Insights
This is a 6-part series describing the products and clinical tools of a laboratory quality improvement project called Region 4 Stork, or R4S.
Pathways Case Studies: December 2022 - Insights
This "Pathways" program provides Anatomic and Clinical Pathology cases that include a history, potential answers, rationale, and relevant references. Cases for December include the following sub-specialties: Bone and Soft Tissue Pathology,...
CPT Codes and LOINC Update: September 2020 - Insights
The following list includes updates posted to mayocliniclabs.com during the month of September