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Hereditary testing by specialty - Insights
Mayo Clinic Laboratories is a one-stop laboratory for hereditary testing, featuring a robust menu of molecular, cytogenic, biochemical, and functional assays that support diagnosis and care.
Diagnostic ecosystem boosts access to timely Alzheimer's disease testing - Insights
Mayo Clinic Laboratories has developed a cutting-edge suite of Alzheimer's disease testing. The newest assays use blood samples, avoiding the need for lumbar punctures to obtain cerebrospinal fluid. The testing suite exemplifies Mayo Clinic...
How an ex-NFL Linebacker Overcame His Greatest Opponent, Amyloidosis - Insights
Matt Millen, ex-pro NFL player, who played on four Super Bowl-winning teams underwent a nearly six-year medical journey in search for answers. Finally, he was diagnosed with amyloidosis using a new testing methodology at Mayo Clinic.
Hepatocellular Carcinoma Risk Panel with GALAD Score - Insights
In this “Hot Topic,” Joshua Bornhorst, Ph.D., assistant professor of laboratory medicine and pathology at Mayo Clinic, reviews biomarker component testing for hepatocellular carcinoma, explains the GALAD score, and explores GALAD score...
Syndromic Testing for Infectious Diseases: Respiratory Infections - Insights
In this month's "Hot Topic," Matthew Binnicker, Ph.D., discusses the use of multiplex panels for the diagnosis of respiratory infections and focuses on the clinical utility of these tests in the setting of upper respiratory tract...
October 2023 - Clinical Microbiology - Insights
This "Pathways" program provides a Clinical Pathology case that includes a history, potential answers, rationale, and relevant references. This case sub-specialty is Clinical Microbiology.
A web of care, close to home: Support on the cancer journey - Insights
Dr. Dollahite received world-class cancer treatment from a web of health care organizations, including Mayo Clinic in Rochester, Minnesota. Yet she never left New York; most of her treatment occurred in Ithaca. What made that possible was...
Frequently asked questions - Insights
For patients at risk of plasma cell disorders, early identification is critical to ensure better outcomes. Mayo Clinic MASSFIX, our innovative approach uses matrix-assisted laser desorption/ionization time-of-flight mass spectrometry...
Frequently asked questions - Insights
For patients at risk of plasma cell disorders, early identification is critical to ensure better outcomes. Mayo Clinic MASSFIX, our innovative approach uses matrix-assisted laser desorption/ionization time-of-flight mass spectrometry...
Global capabilities - Insights
Check out how Mayo Clinic Laboratories optimized global capabilities facilitate individualized solutions that ensure international clients receive expeditious, accurate answers.
MayoComplete next-generation sequencing: Transforming comprehensive cancer care - Insights
Offering increased sensitivity and improved accuracy, MayoComplete next-generation testing ensures health care providers understand the distinctive genetic features of their patients’ cancer to make informed decisions to guide their care.
Cross-laboratory collaboration accelerates gold-standard SRA testing - Insights
Utilizing testing capabilities of two separate laboratory facilities, Mayo Clinic Laboratories’ new serotonin release assay (SRA) is a gold-standard test supported by decades of clinical hematopathologic experience and advanced mass...
Heparin Induced Thrombocytopenia (HIT) and the Role of Serotonin Release Assay (SRA) - Insights
In this month's "Hot Topic," Rajiv Pruthi, M.B.B.S., discusses heparin induced thrombocytopenia (HIT), approach diagnosis, and the role of the functional serotonin release assay (SRA).
Familial Variant Targeted Testing (FMTT) - Insights
In this month's "Hot Topic," Megan Hoenig, M.S., M.P.H., CGC, a licensed and certified genetic counselor with the Division of Laboratory Genetics and Genomics at Mayo Clinic Laboratories, describes the principles and benefits of Familial...
Genetics - Mayo Clinic Laboratories
Our genetic testing was developed by experienced geneticists, genetic counselors, laboratory scientists, and bioinformaticians. We focus on providing easy to understand answers, interpreted by those same individuals who have an intimate...
Neuropathy and Neuromuscular Gene Panel Update - Insights
In this month's "Hot Topic," Christopher Klein, M.D., and Zhiyv (Neal) Niu, Ph.D., discuss how Mayo Clinic’s neuropathy and neuromuscular gene panels have enhanced patient care.
Advancing Multiple Myeloma Diagnosis - Insights
The standard laboratory test to diagnose multiple myeloma dates back to the Eisenhower administration. Research at Mayo Clinic spearheaded by David Murray, M.D., Ph.D. (PATH ’10), and fueled by his experience as an industrial chemist has...
Laboratory Utilization Management: Tick-Borne Disease Testing - Insights
In this month's "Hot Topic," Elitza Theel, Ph.D., will be discussing laboratory utilization management, specifically for diagnostic testing for tick-borne diseases.
Autoimmune testing education - Insights
Mayo Clinic Laboratories is leading an evolution in autoimmune neurology diagnosis. Powered by expertise from our research labs, clinical labs, and Autoimmune Neurology Clinic, we have developed panels customized to address specific...
Epic journey yields unique offering - Insights
The quest to create a test pinpointing the source of the rare, testicular cancer-associated illness successfully concluded in the summer of 2021.
After a long wait, the U.S. Food and Drug Administration has finally approved the Elecsys Troponin T Gen 5 STAT blood test. Recently, the Beckman hscTnI assay was also approved. These high-sensitivity troponin assays will benefit emergency...
COVID-19 & influenza testing algorithm arms Mayo Clinic for the upcoming flu season - Insights
Flu season is just now unfolding. But this time, it’s piggy-backed with a pandemic, which threatens to spike with the colder weather as people huddle indoors. Adding to this conundrum is the unsettling fact that, for both COVID-19 and the...
Top Gun Phlebotomy: Pseudohyperkalemia - Insights
In this month’s “Hot Topic,” Brad Karon, M.D., Ph.D., describes how pseudohyperkalemia has many causes, from collection techniques, processing, and even transport. This presentation focuses on the various preanalytic and analytic causes of...
Sorting through the Details of an Automation Solution - Insights
Laboratories face increasing pressure to automate their operations as they are challenged by a continuing increase in workload, a need to reduce expenditure, and a demand for accuracy and improved turnaround time—essentially doing more with...
August 2023 - Lab Genetics & Genomics - Insights
This "Pathways" program provides a Clinical Pathology case that includes a history, potential answers, rationale, and relevant references. This case sub-specialty is Laboratory Genetics and Genomics.
Neurofilament light chain test helps in diagnosis, treatment, and prognosis of ALS and MS - Insights
By using a test that measures neurofilament light chain (Nfl) proteins in blood, clinicians can better diagnose devastating diseases like ALS and MS, help predict disease progression, and better assess efficacy of existing drugs and trial...
JoAnne Michael’s symptoms started with dizziness and forgetfulness before down spiraling into severe confusion, crying jags, and brain seizures. ER doctors at her local hospital initially thought she was on drugs. JoAnne, terrified,...
Regaining quality of life after a decade lost to misdiagnosis: Kelly Dubois - Insights
Misdiagnosed with acromegaly, a disease marked by too much growth hormone, and plagued by a host of mysterious health problems from unnecessary medications, Kelly DuBois finally found answers after pharmacogenomic testing from Mayo Clinic...
A novel testing approach for newly identified VEXAS syndrome - Insights
VEXAS syndrome is a severe autoinflammatory disease that results in a spectrum of rheumatologic and hematologic conditions. The underlying cause of newly identified VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome —...
Each day, some 40 to 45 thousand specimens are shipped to Mayo Clinic Laboratories in Rochester, Minnesota, from hospitals and other health care organizations around the world. And for every sample, there’s a patient to whom it belongs,...
Mayo Clinic Laboratories: Quality testing from start to finish - Insights
Guided by a patient-centric philosophy, Mayo Clinic Laboratories has a unique internal structure of quality specialists, coordinators, and engineers who constantly evaluate and improve laboratory operations. This structure supports a host...
Mayo Clinic Laboratories isn’t just a reference lab. We’re also the diagnostic lab for a hospital, just like your lab. So we know the many benefits of keeping tests as close to patients as possible.
Synthesizing cardiovascular genetic test results into a unified diagnosis for the patient - Insights
For over two decades, Mayo Clinic has been at the forefront of cardiovascular (CV) genetic testing. The current test menu features 24 different panels that span over 300 genes linked to inherited cardiovascular disorders, many of which are...
Unveiling a novel hemoglobinopathy classification - Insights
In a recent discovery by Mayo Clinic Laboratories, a novel hemoglobinopathy category was identified and termed epsilon gamma thalassemia. The first instance of the disorder was found in 2017 when an obstetric patient underwent a routine...
A "sandbox" for innovation: The Advanced Diagnostics Laboratory - Insights
Mayo Clinic’s Advanced Diagnostics Laboratory (ADL) is a visionary space designed to foster innovation. The ADL has a direct impact on patient lives, bringing promising tests and services to patients at Mayo and around the world.
Comprehensive testing helps diagnose and manage rare genetic disorder: Lauri Sieben - Insights
Multiple doctors and multiple examinations could not figure out why Lauri Sieben had spent much of her life “never feeling quite right” physically. Fortunately for Lauri, that changed after her daughter Christy began working as a genetic...
Since 1992, cases of colorectal cancer have been on a slow decline, yet 52,550 people died from it in 2023. At Mayo Clinic, a cutting-edge menu of both germline (inherited genetic alterations) and somatic (tumors due to non-inherited...
IGHV and TP53 Sequencing: Clinical Utility in Chronic Lymphocytic Leukemia (CLL) - Insights
In this month’s “Hot Topic,” Curtis Hanson, M.D., will discuss the use of laboratory-based prognostic markers in patients with chronic lymphocytic leukemia (CLL). He will also highlight the importance of molecular analyses for IGHV and TP53...
Mayo Clinic Laboratories is one of the few laboratories in the country to offer two special sequencing-based tests for bacteria in its catalog. The first test is designed to help protect patients by investigating potential outbreaks of a...
Pathways Case Studies: February 2022 - Insights
This "Pathways" program provides Anatomic and Clinical Pathology cases that include a history, potential answers, rationale, and relevant references. Cases for February include the following sub-specialties: Clinical Biochemistry, Bone and...
Membranoproliferative glomerulonephritis (MPGN) is a pattern of glomerular injury. Based on the etiology of MPGN, Drs. Sethi and Fervenza proposed a new histologic classification of MPGN into Ig/IC-mediated MPGN and complement-mediated...
Pathways Case Studies: July 2022 - Insights
This "Pathways" program provides Anatomic and Clinical Pathology cases that include a history, potential answers, rationale, and relevant references. Cases for July include the following sub-specialties: Gastroenterology Pathology,...
Pathways Case Studies: October 2022 - Insights
This "Pathways" program provides Anatomic and Clinical Pathology cases that include a history, potential answers, rationale, and relevant references. Cases for October include the following sub-specialties: Cardiovascular Pathology,...
Helicobacter pylori testing: 2021 update - Insights
In this month’s Hot Topic, Robin Patel, M.D., discusses Mayo Clinic Laboratories’ new PCR assay for detection of Helicobacter pylori detection and determination of clarithromycin resistance directly from stool.
Diagnostic Guidelines for Celiac Disease - Insights
In this "Hot Topic," Melissa Snyder, Ph.D., provides a brief review of published guidelines for the diagnosis of celiac disease, with a specific focus on the role of laboratory testing.
Testing for Streptococcus pneumoniae Antibodies - Insights
In this month's "Hot Topic," Melissa Snyder, Ph.D., identifies the clinical application of testing for Streptococcus pneumoniae polysaccharide antibodies and describes the tests available for measuring these antibodies.
MASTERMIND: A Smarter Search for Microbial Diagnostics - Insights
In the war against microbes, human beings are vastly outnumbered—and losing the weapons race.
Understanding the difference between benign and malignant adrenal tumors has alway been difficult; this new assay will assist with this medical challenge.
Neurogenetic Testing - Mayo Clinic Laboratories
We offer comprehensive neurogenetic testing, backed by a multidisciplinary team of clinical neurology experts, laboratory scientists, and genetic counselors, to provide the highest standard for mutation detection and depth of coverage.
Biomarker and companion diagnostic testing - Insights
Browse our suite of diagnostic, therapeutic and prognostic, quantitative and semi-quantitative immunohistochemical stains with interpretation.