Learn more about how Mayo Clinic Laboratories’ unique testing for sphingolipidoses, including Gaucher and Krabbe diseases, can confirm diagnosis and guide disease management.
Pediatric CNS Disorder Testing - Mayo Clinic Laboratories
We offer a first-of-its-kind profile including only the antibodies that are pertinent to pediatric CNS disorders—all in one evaluation.
Neuropathogy at Mayo Clinic Laboratories
Learn more about neuropathology at Mayo Clinic Laboratories, which provides expert second options across the spectrum of neurological disease.
Biologic Therapies: Reflexive Approaches to Optimizing Treatment for IBD - Insights
Many patients may have flare-ups of their disease, or they may stop responding to treatment. In these situations, the clinician may choose to increase the dose administered or recommend more frequent injections. One cause of decreased...
Autoimmune Encephalopathy Testing - Mayo Clinic Laboratories
Our phenotype specific testing for autoimmune encephalopathy contains only clinically relevant antibodies providing accurate answers for treatment guidance.
Autoimmune Encephalopathy Testing - Mayo Clinic Laboratories
Our phenotype specific testing for autoimmune encephalopathy contains only clinically relevant antibodies providing accurate answers for treatment guidance.
Prostate Health Index (phi) [Test in Focus] - Insights
Useful For Assessing the patient’s probability of having detectable prostate cancer when totalprostate specific antigen (PSA) concentrations are between
Hepatitis C Virus Genotypic Antiviral Drug Resistance [Test in Focus] - Insights
Joseph Yao, M.D., gives an overview of this new test available through Mayo Clinic Laboratories. He discusses when this testing should be ordered, how this testing improves upon other testing approaches, and what clinical action can be...
New Tests - Mayo Clinic Laboratories
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Lyme Neuroborreliosis - Insights
In this month’s “Hot Topic,” Elitza Theel, Ph.D., will discuss diagnostic testing options for patients with suspected neuroinvasive Lyme disease or Lyme neuroborreliosis.
GFAP: Novel Test for a Newly Identified Meningoencephalomyelitis - Insights
Mayo Clinic Laboratories is the only laboratory in the world to offer testing for a novel form of autoimmune meningoencephalomyelitis. Known as autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy, the condition was identified...
New tests launched in June - Insights
In June 2023, Mayo Clinic Laboratories announced 28 new tests along with numerous reference value changes, obsolete tests, and algorithm changes.
Autoimmune Epilepsy Testing - Mayo Clinic Laboratories
Our phenotype specific testing for autoimmune epilepsy contains only clinically relevant antibodies providing accurate answers for treatment guidance.
While the diagnostic criteria of celiac disease are well defined, symptoms are generally nonspecific. This fact, combined with the variety of available tests — each with a specific utility and interpretation — can make a diagnosis...
Hepatocellular Carcinoma Risk Panel with GALAD Score - Insights
In this “Hot Topic,” Joshua Bornhorst, Ph.D., assistant professor of laboratory medicine and pathology at Mayo Clinic, reviews biomarker component testing for hepatocellular carcinoma, explains the GALAD score, and explores GALAD score...
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Prenatal - Mayo Clinic Laboratories
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Collagen VII Autoantibody-mediated Subepidermal Autoimmune Blistering Diseases - Insights
In this month’s “Hot Topic,” Julia Lehman, M.D., professor of dermatology and laboratory medicine and pathology, discusses a subepidermal disease mediated by collagen VII autoantibodies.
December 2022 - Renal - Insights
This "Pathways" program provides an Anatomic Pathology case that includes a history, potential answers, rationale, and relevant references. This case sub-specialty is Renal Pathology.
Mayo Clinic Laboratory and Pathology Research Roundup: Oct. 15 - Insights
This week’s Research Roundup highlights paraneoplastic neuronal intermediate filament autoimmunity.
Organic acid disorders - Insights
Check out how Mayo Clinic Laboratories testing for organic acid metabolism disorders can help provide early diagnosis that enable prompt intervention.
Mayo Clinic Laboratories upfront, screening enzyme-linked immunosorbent assay detects Coccidioides antibodies prior to testing by complement fixation (CF) or immunodiffusion (ID). Samples that result as reactive by are subsequently reflexed...
Thrombotic Microangiopathies (TMA) [Test in Focus] - Insights
Meera Sridharan, M.D., Ph.D., explains Mayo Clinic Labs’ testing approach for atypical hemolytic uremic syndrome (aHUS). The serological complement panel examines nine analytes to gain a thorough understanding of the complement cascade to...
Divyanshu Dubey, M.B.B.S., explains how Mayo Clinic Laboratories' unique PDE10A and TRIM46 tests facilitate the management of central nervous system disorders triggered by cancers. Early diagnosis and treatment are important for managing...
Patients with elevated LDL or "bad" cholesterol face even greater risk if their levels of small dense LDL cholesterol are also high. Vlad Vasile, M.D., Ph.D., and Leslie Donato, Ph.D., explain how Mayo Clinic Laboratories' sdLDL-c assay...
Testing aids nicotine-use cessation: Paul Jannetto, Ph.D. - Insights
Tobacco use is the leading cause of preventable death in the United States. In this test-specific episode of the "Answers From the Lab" podcast, Paul Jannetto, Ph.D., explains how Mayo Clinic Laboratories' nicotine testing benefits patients...
fabry_disease_newborn_screen-positive_follow-up.pdf
08/2024© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. Fabry Disease: Newborn Screen-Positive Follow-up False-positive newborn screen Disease-causing variant identified Newborn screen result: Decreased...
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newborn-screen-follow-up-elevated-c3-dc-isolated.pdf
© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. Reviewed 05/2025 Newborn screen result: Isolated elevation of malonylcarnitine (C3-DC) Perform: Blood gas, glucose, electrolytes Order: ■ OAU / Organic...
Mayo Clinic Laboratory and Pathology Research Roundup: July 23 - Insights
This week’s Research Roundup highlights gastrointestinal and extra-intestinal manifestations of immunoglobulin G4-related disease.
Learn more about our comprehensive menu of COVID-19 molecular, serology, and related testing.
Diagnosis and inflammation monitoring - Insights
Patients with symptoms that arouse clinical suspicion of either inflammatory bowel disease (IBD) or irritable bowel syndrome (IBS) are both common and tough to differentiate.
Learn more about how Mayo Clinic Laboratories’ genetic testing for pulmonary conditions can provide diagnostic confirmation for an array of inherited illnesses.
Kelch-11 Autoantibody Test [Test in Focus] - Insights
Divyanshu (Div) Dubey, M.B.B.S., explains how Mayo Clinic Labs’ new Kelch-11 antibody test — the first in the world — can confirm diagnosis, guide treatment, and improve outcomes in patients affected by testicular cancer-associated...
Updates Streamline Autoimmune Neurology Testing: Anastasia Zekeridou, M.D., Ph.D. - Insights
Anastasia Zekeridou, M.D., Ph.D., explains how Mayo Clinic Laboratories' updated panels and methodology boost the accuracy and efficiency of testing for three autoimmune neurology biomarkers. Early diagnosis is key to managing debilitating...
newborn-screen-follow-up-elevated-c5-dc.pdf
© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. Reviewed 05/2025 Newborn screen result: Elevated glutarylcarnitine (C5-DC) Perform: Plasma ammonia, blood gas, glucose, electrolytes Order: ■ OAU / Organic...
newborn-screen-decreased-free-carnitineco.pdf
© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. 06/2023 Newborn screen result: ■ Decreased free carnitine (C0) ■ Other acylcarnitines relatively low Perform: Plasma ammonia, blood gas, glucose,...
ganglioside_antibody_panel_algorithm.pdf
08/2024© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. Ganglioside Antibody Panel Algorithm IgG Monosialo GM1 titer is performed IgM Monosialo GM1 titer is performed IgG Disialo GD1b titer is...
newborn-screen-elevated-c16-c18-acylcarnitine.pdf
© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. 08/2023 Newborn screen result: ■ Elevated C16 acylcarnitine ■ Possible elevated 18:1 acylcarnitine Perform: Plasma ammonia, blood gas, glucose, electrolytes,...
Specimen Collection and Preparation - Mayo Clinic Laboratories
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Updated assay guides diagnosis of autoimmune liver disease: Anne Tebo, Ph.D. - Insights
Anne Tebo, Ph.D., explains how Mayo Clinic Laboratories' updated ALDG2 assay helps with the evaluation of patients with suspected autoimmune liver disease. The panel also helps with the evaluation of liver disease of unknown etiology.
newborn-screen-follow-up-elevated-c14-long-chain-acylcarnitine.pdf
© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. 06/2023 Newborn screen result: Elevated C14:1 with possible elevations of other long-chain acylcarnitine Perform: Plasma ammonia, blood gas, glucose,...
celiac_disease_gluten-free_cascade_test_algorithm.pdf
05/2022© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. STOP No further testing required Celiac Disease Gluten-Free Cascade Test Algorithm Patient following a gluten-free diet with uncertain or...
newborn-screen-elevated-c8-acylcarnitine-lesser-elevations-c6-c10-acylcarnitines.pdf
© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. 08/2023 Newborn screen results: ■ Elevated C8 acylcarnitine ■ Lesser elevations of C6 and C10 acylcarnitines Perform: Glucose, electrolytes, blood gas, liver...
Emergency/Overdose - Mayo Clinic Laboratories
Emergency/Overdose This test is intended to manage an apparent overdose, intoxicated patient, or determine if a specific set of symptoms might be due to the presence of drugs. This test is designed...
demyelinating-neuropathy-evaluation-algorithm.pdf
08/2024© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. Demyelinating Neuropathy Evaluation Algorithm Neurofascin-155 IgG4 IgG Monosialo GM1 titer is performed IgM Monosialo GM1 titer is performed IgG...
newborn-screen-follow-up-elevated-c4-c5-acylcarnitine-elevated-acylcarnitines.pdf
© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. 09/2023 Newborn screen result: ■ Elevated C4 ■ Elevated C5 ■ Possible other acylcarnitine elevations Perform: Plasma ammonia, blood gas, glucose,...
newborn-screen-elevated-c16-oh-c18-oh.pdf
© Mayo Foundation for Medical Education and Research (MFMER). All rights reserved. 08/2023 Newborn screen result: ■ Elevated C16-OH acylcarnitine ■ Possible elevated C18-OH acylcarnitine Perform: Glucose, electrolytes, blood gas, lactate,...
Mayo Clinic Laboratory and Pathology Research Roundup: December 26 - Insights
This week's research roundup feature: Histoplasma and Blastomyces antigen detection assays are commonly used diagnostic tools. However, a high level of cross-reactivity between these antigens prevents definitive pathogen identification by...
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