Frozen sections: Value & challenges - Insights

In this episode of Lab Medicine Rounds, Rondell Graham, M.B.B.S., associate professor of Laboratory Medicine and Pathology at Mayo Clinic, discusses the value and challenges of frozen sections.

Mitochondrial Disease [Test in Focus] - Insights

Linda Hasadsri, M.D., Ph.D., explains how Mayo Clinic Laboratories’ inclusive approach to mitochondrial disease testing expedites diagnosis. Using innovative methodologies like custom reagents and droplet digital PCR enables precision...

Leading pathology's technology transformation - Insights

As chair of Mayo Clinic’s new Division of Computational Pathology and AI in the Department of Laboratory Medicine and Pathology, Jason Hipp, M.D., Ph.D., is eager to employ the most innovative tools available to benefit patients around the...

Building the business of lab medicine - Insights

In part three of the 50th Anniversary series, Mayo Clinic Laboratories looks further outside the walls of Mayo Clinic. With the belief that the latest in diagnostic testing should be available to any patient, no matter where they are...

The evolution of specimen accessioning and delivery - Insights

The last installment of our 50th Anniversary series explores how Mayo Clinic Laboratories pioneered best practices in the area of specimen accessioning and delivery.

Glimmer of Hope: Gregor Heinrich - Insights

While Gregor Heinrich never could have imagined that testicular cancer was related to his problems with his vision and gait, learning he was positive for KLHL11 protein biomarkers meant he could receive treatment for both the cancer and the...

Toxicology testing for patient care - Insights

In this episode, Paul Jannetto, Ph.D., associate professor of laboratory medicine and pathology and director of the Clinical and Forensic Toxicology Lab, Clinical Mass Spectrometry Lab, and Metals Lab at Mayo Clinic, discusses how his three...

Thanksgiving specimen shipment alert - Insights

Due to the Thanksgiving holiday (recognized on Thursday, November 25), Mayo Clinic Laboratories' specimen pickup and delivery schedules will be altered. To ensure that your specimen vitality and turnaround times are not affected, plan...

NELL-1 [Test in Focus] - Insights

Sanjeev Sethi, M.D., Ph.D., discusses how Mayo Clinic Laboratories’ new immunohistochemistry test for the detection of NELL-1 antigen, a biomarker for membranous nephropathy found in 10% to 15% of patients, provides diagnostic certainty and...

Myasthenia Gravis [Test in Focus] - Insights

Christopher Klein, M.D., discusses Mayo Clinic’s updated myasthenia gravis and Lambert-Eaton syndrome testing approach. Automatic reflex to second-line testing saves time and increases sensitivity and specificity to confirm diagnosis in...

Shining light on one family's struggle: Barbara, Deborah, Pamela, and Rylie - Insights

Before testing at Mayo Clinic Laboratories, Barbara Domaille, Deborah Neville, Pamela Neville, and Rylie Ronnenberg thought there could be a genetic connection to the hip problems they shared. After the testing, they knew for sure.

Multiomics: A new model for identifying biomarkers to predict severe COVID-19 outcomes - Insights

predict a more severe course of COVID-19 before the patient gets sick enough to be hospitalized. Until now, there have been no biomarkers that can reliably predict which patients are more likely to have severe...

CPT codes and LOINC update: December 2020 - Insights

The following list includes updates posted to mayocliniclabs.com during the month of December.

Matthew Binnicker, Ph.D., weighs in on pooled molecular testing for SARS-CoV-2 - Insights

At the beginning of the pandemic, pooled testing was seen as a way to potentially conserve valuable testing resources, but logistical hurdles and other challenges have limited its usefulness.

IgA-mediated autoimmune bullous dermatoses - Insights

In this month’s “Hot Topic,” Julia Lehman, M.D., will discuss autoimmune bullous dermatoses, the rare category of blistering skin diseases that are caused by the development of autoantibodies against various constitutive parts of the...

Omicron Variant: Dr. Bill Morice - Insights

This week on "Answers From the Lab," William Morice II, M.D., Ph.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic and president of Mayo Clinic Laboratories, joins the "Answers From the Lab" podcast for his...

Hereditary Oncology Testing [Test in Focus] - Insights

Wei Shen, Ph.D., explains Mayo Clinic Laboratories' new expert-backed, hereditary oncology panels, which use next-generation sequencing to identify genetic mutations linked to increased cancer risk. By only including clinically significant...

Neuroimmunology: Updates and antibody test utilization - Insights

In this month’s “Hot Topic,” Andrew McKeon, M.B., B.Ch., M.D., reviews the use of neurological phenotype-based evaluations, the move away from the paraneoplastic evaluation, and upcoming changes to test profiles.

Sustainable bridges: Lab medicine & cardiology - Insights

In this episode, Jeffrey (Jeff) Meeusen, Ph.D., assistant professor of Laboratory Medicine and Pathology and clinical chemist in the Division of Clinical Core Laboratory Services at Mayo Clinic, discusses the interface between...

Pancreatic Elastase - Insights

Puanani Hopson, D.O., a Mayo Clinic pediatric gastroenterologist, explains the pancreatic elastase test — a screening test that can be useful when symptoms point to the possibility of exocrine pancreatic insufficiency. Dr. Hopson reviews...

Enhanced technology safeguards patient specimens - Insights

Mayo Clinic's use of enhanced radio-frequency identification technology to track specimens from the clinical setting to the lab reduces the risk of errors and protects valuable — sometime irreplaceable — patient samples.

Reversing a dire disorder: Lorinda McKinley - Insights

Advanced testing at Mayo Clinic Laboratories that confirmed a diagnosis of myasthenia gravis put Lorinda McKinley on the road to renewed health after she nearly lost it all to the rare autoimmune disease.

Thrombotic Microangiopathies (TMA) [Test in Focus] - Insights

Meera Sridharan, M.D., Ph.D., explains Mayo Clinic Labs’ testing approach for atypical hemolytic uremic syndrome (aHUS). The serological complement panel examines nine analytes to gain a thorough understanding of the complement cascade to...

West Nile virus [Test in Focus] - Insights

Bobbi Pritt, M.D., discusses how Mayo Clinic Labs’ updated PCR assay for West Nile virus provides increased sensitivity to detect virus RNA in multiple sources, identifies two virus lineages, and confirms diagnosis.

Embracing the transformative power of digital pathology - Insights

Mayo Clinic is harnessing the extraordinary potential of digital pathology through a robust initiative that’s using the technology to enhance patient care. Mayo’s Dermatology Department is an early adopter, and clinicians, students, and...

Candida Auris: Dr. Nancy Wengenack - Insights

Nancy Wengenack, Ph.D., director of the Mycology and Microbacteriology Laboratories in Mayo Clinic’s Department of Laboratory Medicine and Pathology, joins the "Answers From the Lab" podcast this week. In this episode, Dr. Wengenack and...

Memorial Day Specimen Shipment Alert - Insights

Due to the Memorial Day holiday (recognized on Monday, May 31), Mayo Clinic Laboratories' specimen pickup and delivery schedules will be altered. To ensure that your specimen vitality and turnaround times are not affected, plan ahead and...

Labor Day specimen shipment alert - Insights

Due to the Labor Day holiday (recognized on Monday, September 6), Mayo Clinic Laboratories' specimen pickup and delivery schedules will be altered.

Independence Day Specimen Shipment Alert - Insights

Due to the Independence Day holiday, Mayo Clinic Laboratories' specimen pickup and delivery schedules will be altered. To ensure that your specimen vitality and turnaround times are not affected, plan ahead.

Autoimmune Axonal Evaluation - Insights

Div Dubey, M.B.B.S., explains Mayo Clinic Laboratories' phenotypic testing approach for autoimmune axonal neuropathy. The comprehensive, serologic panel detects for antibodies with clinical relevance to the disease to provide clarity on...

MAG Antibody Testing [Test in Focus] - Insights

John Mills, Ph.D., explains Mayo Clinic Laboratories’ approach to MAG antibody testing. The ELISA-based assay uses higher reference ranges and human MAG antigen to detect MAG antibodies, which are associated with a rare, hard-to-treat...

T-cell Lymphoma [Test in Focus] - Insights

Andrew Feldman, M.D., discusses the different tools and techniques Mayo Clinic Laboratories uses to accurately diagnose and classify T-cell lymphomas to help provide clinicians with the diagnostic answers they need to treat their patients.

Disaccharidase Activity Panel [Test in Focus] - Insights

Pua Hopson, D.O., discusses Mayo Clinic Labs’ new disaccharidase activity panel, which measures levels of five digestive enzymes to identify deficiencies that cause carbohydrate maldigestion and can lead to chronic conditions like celiac...

Focused Pharmacogenomics Panel [Test in Focus] - Insights

Ann Moyer, M.D., Ph.D., explains Mayo Clinic Labs’ new focused pharmacogenomics panel, a real-time, PCR-based testing approach that assesses 10 genes known for their drug-gene associations, to provide guidance on medication selection for...

Direct immunofluorescence for autoimmune bullous diseases - Insights

In this month’s “Hot Topic,” Julia Lehman, M.D., discusses a recent change to the direct immunofluorescence assay, specifically the addition of the IgG4 conjugate.

Autoimmune Profile Updates [Test in Focus] - Insights

Andrew McKeon, M.B., B.Ch., M.D., discusses updates that are being made to Mayo Clinic Laboratories' autoimmune profile that will remove some antibodies from those profiles. He describes the rationale behind the updates, reviews which...

A "sandbox" for innovation: The Advanced Diagnostics Laboratory - Insights

Mayo Clinic’s Advanced Diagnostics Laboratory (ADL) is a visionary space designed to foster innovation. The ADL has a direct impact on patient lives, bringing promising tests and services to patients at Mayo and around the world.

Mayo Clinic Laboratory and pathology research roundup: December 14 - Insights

This week’s research roundup features: Renal Neoplasia in Polycystic Kidney Disease: An assessment of Tuberous Sclerosis complex-associated Renal Neoplasia and PKD1/TSC2 contiguous gene deletion syndrome.

Mayo Clinic Laboratory and Pathology Research Roundup: March 5 - Insights

comprised of missense or intronic variants, have been identified in BRCA2, the few missense variants now classified clinically as pathogenic or likely pathogenic are predominantly located in the region encoding...

Talking omicron with Matthew Binnicker, Ph.D. - Insights

With the omicron variant grabbing headlines around the world, media outlets have turned to experts like Dr. Binnicker to help clarify the effect this new variant could have and what it might mean for the COVID-19 pandemic.

MCL Education releases phlebotomy safety module - Insights

In this Phlebotomy Module, learners will be informed about safety. Bloodborne pathogens, PPE, and infection prevention control will be discussed.

COVID-19 Variants: Dr. Bill Morice - Insights

William Morice II, M.D., Ph.D., chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic and president of Mayo Clinic Laboratories, joins the "Answers From the Lab" podcast for his weekly leadership update. In this...

Hereditary oncology: Molecular testing for solid tumors - Insights

In this episode of Lab Medicine Rounds, Sounak Gupta, M.B.B.S., Ph.D., assistant professor of Laboratory Medicine and Pathology at Mayo Clinic, discusses hereditary oncology and the importance of performing molecular testing of solid...

Cardiovascular laboratory: Biomarkers, testing, & clinical implications - Insights

In this episode, Vlad Vasile, M.D., Ph.D., assistant professor of Laboratory Medicine and Pathology and cardiologist at Mayo Clinic, discusses cardiovascular risk testing, including biomarkers and clinical implications.

Kelch-11 Autoantibody Test [Test in Focus] - Insights

Divyanshu (Div) Dubey, M.B.B.S., explains how Mayo Clinic Labs’ new Kelch-11 antibody test — the first in the world — can confirm diagnosis, guide treatment, and improve outcomes in patients affected by testicular cancer-associated...

The Region 4 Stork (R4S) Collaborative Project - Insights

This is a 6-part series describing the products and clinical tools of a laboratory quality improvement project called Region 4 Stork, or R4S.

MayoComplete Solid Tumor Panel - Insights

Kevin Halling, M.D., Ph.D., explains how the MayoComplete Solid Tumor panel uses next-generation sequencing to assess 514 clinically significant, cancer-related genes for genetic alterations that offer insight on treatment effectivity.

Christmas and New Year's specimen shipment alert - Insights

Due to the Christmas and New Year's holiday's (recognized on Saturday, December 25th, and Saturday, January 1st ), Mayo Clinic Laboratories' specimen pickup and delivery schedules will be altered. To ensure that your specimen vitality and...

Modified two-tiered testing for Lyme disease - Insights

In this month’s “Hot Topic,” Elitza Theel, Ph.D., discusses the modified two-tiered testing algorithm for Lyme disease entirely based on enzyme immunoassays (EIA).

Our Staff, Our Stories: Darin Kittleson - Insights

From friendly neighbor, to a hero. Darin Kittleson was in the middle of his ordinary day snow plowing his driveway when he decided to plow his neighbor’s driveway, as well. That was when he heard the cry for help. Darin rushed inside as 911...