The diagnosis of Myeloproliferative Neoplasm (MPN) must include an integrated approach and combine the clinical findings with laboratory results. In our latest “Hot Topic,” Rong He, M.D., discusses the subclassification of MPNs and the use...
Helicobacter pylori Infection: Serologic Testing Not Recommended [Communiqué] - Insights
Helicobacter pylori (H pylori) infection is among the most common bacterial infections worldwide with approximately one-half of the world’s population infected. Several invasive and noninvasive testing methods are available to detect H...
Chromogenic Factor VIII and IX Assays: Impact on Diagnosis and Management of Hemophilia - Insights
In this month’s “Hot Topic,” Rajiv Pruthi, M.B.B.S., will discuss different types of hemophilia along with their pathologic basis. He will also cover various types of factor assays such as one stage and chromogenic factor assays for...
Infective Endocarditis - Insights
In this month’s “Hot Topic,” Robin Patel, M.D., will review the laboratory methods used to diagnose infectious endocarditis. Specifically, she’ll discuss the role of blood cultures, nucleic acid amplification tests, histopathology, and...
Pathways Case Studies: February 2023 - Insights
This "Pathways" program provides Anatomic and Clinical Pathology cases that include a history, potential answers, rationale, and relevant references. Cases for February include the following sub-specialties: Clinical Informatics,...
Updated Test Promises Fewer False Positives in Newborn Screening for Krabbe Disease - Insights
Mayo Clinic’s Biochemical Genetics Laboratory has announced an updated second-tier test to detect Krabbe disease (KD) that uses psychosine (PSY) as a disease marker. The new test method has significantly higher sensitivity to detect this...
Alzheimer's Disease Testing - Mayo Clinic Laboratories
We have developed an innovative evaluation for Alzheimer's disease, which uses CSF biomarkers to achieve a high concordance with amyloid PET scan.
Justin Fugelsang and Zach Pedowitz have never met. Yet both young men were diagnosed with a rare form of Charcot-Marie-Tooth disease, called sorbitol dehydrogenase (SORD) deficiency, and both found clarity through Mayo Clinic Laboratories'...
The Prostate Health Index (phi) in Prostate Cancer Risk Assessment - Insights
In this month’s “Hot Topic,” Alicia Algeciras-Schimnich, Ph.D., will provide you with valuable information regarding the utility of the prostate specific antigen test, and how the calculation of a prostate health index, or phi, can help to...
In this month’s “Hot Topic,” Paul Jannetto, Ph.D., discusses the high-resolution targeted opioid screening test from Mayo Clinic Laboratories, which offers sensitivity and specificity for use in the monitoring and management of patients who...