Multiomics: A new model for identifying biomarkers to predict severe COVID-19 outcomes - Insights
In a groundbreaking study, Mayo Clinic investigators have developed a multiomic molecular method to predict clinical COVID-19 (SARS-CoV-2) outcomes better than traditional cytokines. Using a machine-learning-based prediction model, the team...
Whole exome sequencing - Insights
Learn more about how whole exome sequencing at Mayo Clinic Laboratories can quickly end diagnostic testing odysseys for patients with suspected genetic disorders.
MCL @Work: Robin Huiras-Carlson - Insights
Robin Huiras-Carlson's connection with Mayo Clinic traces back to her early years, marked by a diagnosis of a rare genetic condition at the age of 10. Today, as a senior marketing specialist with Mayo Clinic Laboratories, she draws...
New high-resolution urine drug testing profile - Insights
Bringing together advanced testing technology, unparalleled expertise, and a patient-focused approach, Mayo Clinic Laboratories’ new high-resolution urine drug testing profile, ADMPU, evaluates for 22 drug classes including alcohol,...
MCL @Work: Jane Hermansen - Insights
Outreach manager Jane Hermansen regards Mayo Clinic as the pinnacle of healthcare. Having spent her formative years in Minnesota, she was inspired by her uncle Roger to embark on a path as a laboratory scientist. Presently, she oversees the...
An inside look at the state-of-the-art supports enabling invention - Insights
A web of innovation within Mayo Clinic Laboratories links research and test development with clinical practice, enabling for some of the world’s most pioneering methodologies. Underpinning this innovation network are unique supports that...
Krabbe disease added to federal newborn screening panel - Insights
Thanks to advocacy work by a group of medical experts, including some from Mayo Clinic, the U.S. Department of Health and Human Services now recommends all states screen for infantile Krabbe disease to help save newborn lives.
Converging on a major milestone in digital pathology - Insights
Successful implementation of a new slide scanning and analysis platform across five laboratories represents a significant step forward in Mayo Clinic’s digital pathology program — an initiative that combines advanced technology with human...
Autoimmune testing education - Insights
Mayo Clinic Laboratories is leading an evolution in autoimmune neurology diagnosis. Powered by expertise from our research labs, clinical labs, and Autoimmune Neurology Clinic, we have developed panels customized to address specific...
Laboratory Utilization Management: Tick-Borne Disease Testing - Insights
In this month's "Hot Topic," Elitza Theel, Ph.D., will be discussing laboratory utilization management, specifically for diagnostic testing for tick-borne diseases.
MayoComplete Next-Generation Sequencing: Oncology Subpanels - Insights
In this month's "Hot Topic," Kevin Halling, M.D., Ph.D., discusses new next generation sequencing testing for various tumor types and the rationale for the enhancements that were made; reviews gene additions that are now available in each...
How an ex-NFL Linebacker Overcame His Greatest Opponent, Amyloidosis - Insights
Matt Millen, ex-pro NFL player, who played on four Super Bowl-winning teams underwent a nearly six-year medical journey in search for answers. Finally, he was diagnosed with amyloidosis using a new testing methodology at Mayo Clinic.
Amid COVID-19 upheaval, DLMP staff steps up - Insights
When COVID-19 hit, staff in Laboratory Medicine and Pathology at Mayo Clinic rose to the challenge with perseverance, flexibility, and resilience.
Epic journey yields unique offering - Insights
The quest to create a test pinpointing the source of the rare, testicular cancer-associated illness successfully concluded in the summer of 2021.
Diagnostic ecosystem boosts access to timely Alzheimer's disease testing - Insights
Mayo Clinic Laboratories has developed a cutting-edge suite of Alzheimer's disease testing. The newest assays use blood samples, avoiding the need for lumbar punctures to obtain cerebrospinal fluid. The testing suite exemplifies Mayo Clinic...
Learn more about Mayo Clinic Laboratories testing for pregnancy loss, which can help determine causes and risk of recurrence for future pregnancies.
A novel testing approach for newly identified VEXAS syndrome - Insights
VEXAS syndrome is a severe autoinflammatory disease that results in a spectrum of rheumatologic and hematologic conditions. The underlying cause of newly identified VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) syndrome —...
Synthesizing cardiovascular genetic test results into a unified diagnosis for the patient - Insights
For over two decades, Mayo Clinic has been at the forefront of cardiovascular (CV) genetic testing. The current test menu features 24 different panels that span over 300 genes linked to inherited cardiovascular disorders, many of which are...
Unveiling a novel hemoglobinopathy classification - Insights
In a recent discovery by Mayo Clinic Laboratories, a novel hemoglobinopathy category was identified and termed epsilon gamma thalassemia. The first instance of the disorder was found in 2017 when an obstetric patient underwent a routine...
Neurofilament light chain test helps in diagnosis, treatment, and prognosis of ALS and MS - Insights
By using a test that measures neurofilament light chain (Nfl) proteins in blood, clinicians can better diagnose devastating diseases like ALS and MS, help predict disease progression, and better assess efficacy of existing drugs and trial...
Hematology Testing - Mayo Clinic Laboratories
Our comprehensive test menu has beencreated to aid in the diagnosis and treatmentselection across the full spectrum of hematologicdisorders.
Since 1992, cases of colorectal cancer have been on a slow decline, yet 52,550 people died from it in 2023. At Mayo Clinic, a cutting-edge menu of both germline (inherited genetic alterations) and somatic (tumors due to non-inherited...
FISH testing helps detect unseen cancer cells: Shannon Camlek - Insights
On the brink of losing her battle with acute myeloid leukemia, Shannon Camlek arrived at Mayo Clinic as a last hope. Her chances didn’t look good, but with the help of specialized genetic testing, particularly FISH (fluorescence in situ...
The birth of Mayo Clinic Laboratories: From tiny operation to international mainstay - Insights
In 1971, the Regional Laboratory, later to become Mayo Clinic Laboratories, was founded. For the first time in Mayo Clinic’s history, the institution would support the community practice of pathology for outside patients in the region and...
Heparin Induced Thrombocytopenia (HIT) and the Role of Serotonin Release Assay (SRA) - Insights
In this month's "Hot Topic," Rajiv Pruthi, M.B.B.S., discusses heparin induced thrombocytopenia (HIT), approach diagnosis, and the role of the functional serotonin release assay (SRA).
Diagnostic Guidelines for Celiac Disease - Insights
In this "Hot Topic," Melissa Snyder, Ph.D., provides a brief review of published guidelines for the diagnosis of celiac disease, with a specific focus on the role of laboratory testing.
October 2023 - Clinical Microbiology - Insights
This "Pathways" program provides a Clinical Pathology case that includes a history, potential answers, rationale, and relevant references. This case sub-specialty is Clinical Microbiology.
Top Gun Phlebotomy: Pseudohyperkalemia - Insights
In this month’s “Hot Topic,” Brad Karon, M.D., Ph.D., describes how pseudohyperkalemia has many causes, from collection techniques, processing, and even transport. This presentation focuses on the various preanalytic and analytic causes of...
MayoComplete next-generation sequencing: Transforming comprehensive cancer care - Insights
Offering increased sensitivity and improved accuracy, MayoComplete next-generation testing ensures health care providers understand the distinctive genetic features of their patients’ cancer to make informed decisions to guide their care.
Progressive alliance advances science through patient-powered research - Insights
Tying together the expertise and curiosity of Mayo Clinic autoimmune neurology researchers with eager patients who have rare disease and are looking for answers, the innovative collaboration benefits both patients affected by MOGAD and...
Pushing the envelope on personalized medicine - Insights
Recognizing the powerful role genes can play in diagnosing illness and guiding treatment, the Division of Laboratory Genetics and Genomics at Mayo Clinic spearheaded a testing expansion, implementing and upgrading more than 60 advanced...
Lyme Neuroborreliosis - Insights
In this month’s “Hot Topic,” Elitza Theel, Ph.D., will discuss diagnostic testing options for patients with suspected neuroinvasive Lyme disease or Lyme neuroborreliosis.
Performed on cerebrospinal fluid, Mayo Clinic’s RT-QuIC prion test can distinguish prion disease from other types of rapidly progressive dementias to enhance patient care.
Forging ahead after years of hardship: Anya Magnuson - Insights
At just 24-years-old Anya Magnuson has survived not just one but two close encounters with death. Focused, determined, and intent on experiencing life to its fullest, Anya never gave up. Nor did the multidisciplinary Mayo Clinic care team...
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) - Insights
In this month's "Hot Topic," Eoin Flanagan, M.B., B.Ch., reviews the recent diagnostic criteria for Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease (MOGAD).
Gadolinium-based contrast agents (GBCAs) have revolutionized MRIs by increasing the clinical utility and detection sensitivity of these exams. GBCAs also contain gadolinium, a rare earth metal with unique chemical properties. This article...
Surprises in Coagulation Testing - Insights
In this “Hot Topic,” William Nichols, M.D., presents a case study that demonstrates how pre- and postanalytic variables of the patient and blood samples can have confounding effects on the laboratory evaluation of coagulation disorders.
Learn more about matrix-assisted laser desorption/ionization-time of flight mass spectrometry and the identification of plasma cell disorders.
Autoimmune Encephalitis Misdiagnosis - Insights
In this month's "Hot Topic," Eoin Flanagan, M.B., B. Ch., discusses the important issue of autoimmune encephalitis misdiagnosis and identifies red flags that be useful in clinical practice to suggest alternative diagnoses and highlight...
In this month's "Hot Topic," Bobbi Pritt, M.D., describes the challenges to traditional microscopy for the detection of protozoa in stool specimens, lists potential uses of artificial intelligence in parasite detection, and discusses...
Chromogenic Factor VIII and IX Assays: Impact on Diagnosis and Management of Hemophilia - Insights
In this month’s “Hot Topic,” Rajiv Pruthi, M.B.B.S., will discuss different types of hemophilia along with their pathologic basis. He will also cover various types of factor assays such as one stage and chromogenic factor assays for...
Alzheimer's Disease CSF Biomarkers - Insights
In this month's "Hot Topic," Alicia Algeciras, Ph.D., DABCC, and Joshua Bornhorst, Ph.D., DABCC, discuss Alzheimer's disease CSF biomarkers.
PD-L1 Testing by Immunohistochemistry - Insights
In this month's "Hot Topic," Anja Roden, M.D., discusses the role of PD-L1 interaction in the immune system, challenges of PD-L1 testing, and current PD-L1 companion testing in various tumor types.
Behind the scenes in neural antibody testing - Insights
In this month’s “Hot Topic,” John Mills, Ph.D., explains the central role of tissue immunofluorescence in the identification of neural antibodies and discusses the benefits of an integrated laboratory approach to the development and...
The Secrets of Cryoprecipitate: A Blood Banking Process - Insights
In this month’s “Hot Topic,” Jessie Swanson and Michelle Soland from the Component Laboratory will discuss the process improvement that helped decrease the standard cryoprecipitate dosage and the positive impact it has on patients.