A short description of the method used to perform the test
Direct Radioimmunoassay (RIA)
NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Lists a shorter or abbreviated version of the Published Name for a test
Gonadotropin Releasing Hormone
Lists additional common names for a test, as an aid in searching
Gonadotropin Releasing Hormone (Gn-RH)
Luteinizing Hormone-Releasing Hormone
Describes the specimen type validated for testing
Defines the optimal specimen required to perform the test and the preferred volume to complete testing
Patient should not be on any Steroid, ACTH, Gonadotropin, or Estrogen medications, if possible, for at least 48 hours prior to collection.
Specimen Type: Serum
Container/Tube: Red top or SST
Specimen Volume: 3 mL
Collection Instructions: Draw blood in a plain, red-top tube(s), serum-gel tube(s) is acceptable. Separate immediately and send 3 mL of serum frozen in a plastic vial.
Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the Testing Laboratory
Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected
| Hemolysis || Mild reject; Gross reject |
| Lipemia || Mild reject; Gross reject |
| Icterus || Mild reject; Gross reject |
| Other || Specimens other than Serum or Plasma EDTA listed. |
Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Gonadotropin-Releasing Hormone (Gn-RH), also known as Luteinizing Hormone-Releasing Hormone (LH-RH), is a decapeptide secreted pulsatily from the hypothalamus. It stimulates the release of the Gonadotropins - Luteinizing Hormone and Follicle Stimulating Hormone - exerting a stronger effect on Luteinizing Hormone. Testosterone and Estradiol, whose release is stimulated by the Gonadotropins, exert a negative feedback control on LH-RH both at the hypothalamic site and by decreasing pituitary receptor binding. LH-RH levels are low in patients with hypothalamic hypogonadism differentiating them from the high levels usually found in primary hypopituitary hypogonadism. Accentuation of the LH-RH pulse occurs at the onset of puberty triggering the release of LH and FSH required in pubertal development. LH-RH is stimulated by Epinephrine and suppressed by Dopamine and opiates. LH-RH and some of its agonists are frequently used to induce ovulation.
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Adult Reference Range(s):
Males: 4.0 - 8.0 pg/mL
Females: 2.0 - 10.0 pg/mL
No pediatric reference ranges available for this test.
Recommendations for in-depth reading of a clinical nature
1. J Schopohl, G Mehltretter, R von Zumbusch, T Eversmann, and L von Werder. Comparison of Gonadotropin-Releasing Hormone and Gonadotropin Therapy in Male Patients with Idiopathic Hypogonadism. Fertility and Sterility 56: 1143-1150, 1991.
2. CB Lambalk, J Schoemaker, GP van Rees, J de Koning, and HAMJ van Dieten. Exogenous versus Endogenous Pulses of Luteinizing Hormone-Releasing Hormone and Secretory Patterns of Gonadotropins. Fertility and Sterility 56: 446-452, 1991.
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.
- Authorized users can sign in to Test Prices for detailed fee information.
- Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
- Prospective clients should contact their Regional Manager. For assistance, contact Customer Service.
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.
This test was developed and itâ€™s performance characteristics determined by Inter Science Institute. It has not been cleared or approved by the US Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary.
CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
CPT codes are provided by the performing laboratory.
Test Setup Resources
Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.
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SI Sample Reports
International System (SI) of Unit reports are provided for a limited number of tests. These reports are intended for international account use and are only available through MayoLINK accounts that have been defined to receive them.
SI Normal Reports |
SI Abnormal Reports