A short description of the method used to perform the test
Direct Radioimmunoassay (RIA)
NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Lists a shorter or abbreviated version of the Published Name for a test
Elastase (Pancreatic Elastase 1), S
Lists additional common names for a test, as an aid in searching
Describes the specimen type validated for testing
Defines the optimal specimen required to perform the test and the preferred volume to complete testing
Draw blood in a plain, red-top or a serum gel tube(s). Separate immediately and send 3 mL of serum frozen in a plastic vial.
Note: 1. Indicate serum on request form.
2. Label specimen appropriately (serum).
1. The patient should fast for 10 to 12 hours prior to collection.
2. Medications that affect pancreatic activity should be discontinued, if possible, for at least 48 hours prior to collection of specimen.
Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the Testing Laboratory
Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected
| Specimens other than || Serum |
| Anticoagulants other than || NA |
| Hemolysis || Mild reject; Gross reject |
| Lipemia || Mild reject; Gross reject |
| Icteric || NA |
Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Serum Elastase, also called Pancreatopeptidase, is a protease present in pancreatic secretion with the unique ability to rapidly hydrolyze elastin. Elastin is a fibrillar protein found in connective tissue. Elastin forms the elastic fibers found mostly in lungs and skin. Elastase is able to hydrolyze denatured hemoglobin, casein, fibrin, albumin and denatured but not native collagen. Elastase has been implicated in the pathogenesis of pulmonary emphysema, atherosclerosis and in the vascular injury of acute pancreatic necrosis. Elastase activity is inhibited by protease inhibitors including a1-Anti-Trypsin, a1-anti-Chymotrypsin, anti-Thrombin III, a2-Macroglobulin and b1-anti-Collagenase. Patients with thyroid dysfunction have decreased Elastase activity. Serum pancreatic levels quantify EL 1 for the diagnosis or exclusion of an acute pancreatitis or an inflammatory episode of chronic pancreatitis or gallstone induced pancreatitis.
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Adult Reference Ranges:
Normal pancreatic exocrine function:
Less than 3.5 ng/mL
No pediatric reference ranges available for this test.
Test Setup Resources
Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.
Excel | Pdf
SI Sample Reports
International System (SI) of Unit reports are provided for a limited number of tests. These reports are intended for international account use and are only available through MayoLINK accounts that have been defined to receive them.
SI Normal Reports |
SI Abnormal Reports