Direct Radioimmunoassay (RIA)
Draw blood in a plain, red-top or a serum gel tube(s). Separate immediately and send 3 mL of serum frozen in a plastic vial.
Note: 1. Indicate serum on request form.
2. Label specimen appropriately (serum).
1. The patient should fast for 10 to 12 hours prior to collection.
2. Medications that affect pancreatic activity should be discontinued, if possible, for at least 48 hours prior to collection of specimen.
If not ordering electronically, complete, print, and send Gastroenterology and Hepatology Client Test Request (T728) with the specimen.
|Specimens other than||Serum|
|Anticoagulants other than||NA|
|Hemolysis||Mild reject; Gross reject|
|Lipemia||Mild reject; Gross reject|
|Specimen Type||Temperature||Time||Special Container|
|Serum||Frozen (preferred)||180 days|
Serum Elastase, also called Pancreatopeptidase, is a protease present in pancreatic secretion with the unique ability to rapidly hydrolyze elastin. Elastin is a fibrillar protein found in connective tissue. Elastin forms the elastic fibers found mostly in lungs and skin. Elastase is able to hydrolyze denatured hemoglobin, casein, fibrin, albumin and denatured but not native collagen. Elastase has been implicated in the pathogenesis of pulmonary emphysema, atherosclerosis and in the vascular injury of acute pancreatic necrosis. Elastase activity is inhibited by protease inhibitors including a1-Anti-Trypsin, a1-anti-Chymotrypsin, anti-Thrombin III, a2-Macroglobulin and b1-anti-Collagenase. Patients with thyroid dysfunction have decreased Elastase activity. Serum pancreatic levels quantify EL 1 for the diagnosis or exclusion of an acute pancreatitis or an inflammatory episode of chronic pancreatitis or gallstone induced pancreatitis.
Normal pancreatic exocrine function:
Less than 3.5 ng/mL
No pediatric reference ranges available for this test.
Monday through Friday
|Test Id||Test Order Name||Order LOINC Value|
|FELAS||Elastase (Pancreatic Elastase 1), S||14048-3|
|Result Id||Test Result Name||
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.