Patient preparation: Patient should fast overnight prior to collection of specimen.
Specimen Type: Plasma
Container/Tube: Z tube
Specimen Volume: 3 mL
Collection Instructions: Draw 10 mL of blood in special Z-tube (MCL T701). Separate plasma from cells immediately after draw and send 3 mL of plasma frozen in plastic vial.
|Hemolysis||Mild reject; Gross reject|
|Lipemia||Mild reject; Gross reject|
|Other||Specimens other than collected in Z tube (MCL T701).|
|Specimen Type||Temperature||Time||Special Container|
|Plasma||Frozen (preferred)||90 days|
The ISI plasma 5-HIAA assay correlates well with the 24-hour urinary 5-HIAA assays. This test has been clinically validated for NETS patients who previously relied on the 24-hour urinary 5-HIAA. The plasma 5-HIAA saves time, alleviates the need to collect urine in a container for 24 hours, and provides equivalent clinical information.
Up to 22 ng/mL
1. Tellez MR, Mamikunian G, O'Dorisio TM et al. A single fasting plasma 5-HIAA value correlates with 24-hour urinary 5-HIAA values and other biomarkers in midgut neuroendocrine tumors (NETs). Pancreas. 2013:42(3): 405-410.
2. Cai H-L, Zhu R-H, Li H-D, et al. MultiSimplex optimization of chromatographic separation and dansyl derivatization conditions in the ultra performance liquid chromatography-tandem mass spectrometry analysis of neurotransmitters in human urine. J Chromato B 2011;879:1993-1999.
3. Gonzalez RR, Fernandez RF, Vidal JLM et al. Development and validation of an ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method for the simultaneous determination of neurotransmitters in rat brain samples. J Neuro Meth 2011;198: 187-194.
4. Stephanson N, Helander A, Beck O. Alcohol biomarker analysis: simultaneous determination of 5-hydroxytryptophol glucuronide and 5-hydroxyindoleacetic acid by direct injection of urine using ultra-performance liquid chromatographytandem mass spectrometry. J Mass Spect 2007;42: 940-949.
Monday through Friday
This GCMS assay was developed and its performance characteristics determined by Inter Science Institute. It has not been cleared or approved by the FDA and such approval or clearance is not required at this time. Values obtained with different methods, different laboratories or with kits cannot be used interchangeably with the results on this report. The results cannot be interpreted as absolute evidence of the presence or absence of malignant disease.
|Test Id||Test Order Name||Order LOINC Value|
|Result Id||Test Result Name||
Result LOINC Value
Result LOINC Value Tooltip