Describes the specimen type validated for testing
Defines the optimal specimen required to perform the test and the preferred volume to complete testing
Patient preparation: Patient should fast overnight prior to collection of specimen.
Specimen Type: Plasma
Container/Tube: Z tube
Specimen Volume: 3 mL
Collection Instructions: Draw 10 mL of blood in special Z-tube (MCL T701). Separate plasma from cells immediately after draw and send 3 mL of plasma frozen in plastic vial.
Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the Testing Laboratory
Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected
| Hemolysis || Mild reject; Gross reject |
| Lipemia || Mild reject; Gross reject |
| Icterus || NA |
| Other || Specimens other than collected in Z tube (MCL T701). |
Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
The ISI plasma 5-HIAA assay correlates well with the 24-hour urinary 5-HIAA assays. This test has been clinically validated for NETS patients who previously relied on the 24-hour urinary 5-HIAA. The plasma 5-HIAA saves time, alleviates the need to collect urine in a container for 24 hours, and provides equivalent clinical information.
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Recommendations for in-depth reading of a clinical nature
1. Tellez MR, Mamikunian G, O'Dorisio TM et al. A single fasting plasma 5-HIAA value correlates with 24-hour urinary 5-HIAA values and other biomarkers in midgut neuroendocrine tumors (NETs). Pancreas. 2013:42(3): 405-410.
2. Cai H-L, Zhu R-H, Li H-D, et al. MultiSimplex optimization of chromatographic separation and dansyl derivatization conditions in the ultra performance liquid chromatography-tandem mass spectrometry analysis of neurotransmitters in human urine. J Chromato B 2011;879:1993-1999.
3. Gonzalez RR, Fernandez RF, Vidal JLM et al. Development and validation of an ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method for the simultaneous determination of neurotransmitters in rat brain samples. J Neuro Meth 2011;198: 187-194.
4. Stephanson N, Helander A, Beck O. Alcohol biomarker analysis: simultaneous determination of 5-hydroxytryptophol glucuronide and 5-hydroxyindoleacetic acid by direct injection of urine using ultra-performance liquid chromatographytandem mass spectrometry. J Mass Spect 2007;42: 940-949.
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.
- Authorized users can sign in to Test Prices for detailed fee information.
- Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
- Prospective clients should contact their Regional Manager. For assistance, contact Customer Service.
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.
This GCMS assay was developed and its performance characteristics determined by Inter Science Institute. It has not been cleared or approved by the FDA and such approval or clearance is not required at this time. Values obtained with different methods, different laboratories or with kits cannot be used interchangeably with the results on this report. The results cannot be interpreted as absolute evidence of the presence or absence of malignant disease.
CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.
CPT codes are provided by the performing laboratory.
Provides guidance in determining the Logical Observation Identifiers Names and Codes (LOINC) values for the order and results codes of this test. LOINC values are provided by the performing laboratory.
||Test Order Name
Order LOINC Value
||Test Result Name
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
Test Setup Resources
Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.
SI Sample Reports
International System (SI) of Unit reports are provided for a limited number of tests. These reports are intended for international account use and are only available through MayoLINK accounts that have been defined to receive them.
SI Normal Reports |
SI Abnormal Reports