Useful For
Suggests clinical disorders or settings where the test may be helpful
Determining glomerular filtration rate in urine specimens
Method Name
A short description of the method used to perform the test
NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.
Yes
Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test
Iohexol, U
Specimen Type
Describes the specimen type validated for testing
Urine
Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing
Supplies: Sarstedt 5 mL Aliquot Tube (T914)
Container/Tube: Plastic vial
Specimen Volume: 5 mL
Collection Instructions: Collect a timed urine specimen.
Forms
Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the Testing Laboratory
Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability. |
Specimen Type |
Temperature |
Time |
Special Container |
Urine |
Refrigerated (preferred) |
7 days |
|
|
Frozen |
35 days |
|
Useful For
Suggests clinical disorders or settings where the test may be helpful
Determining glomerular filtration rate in urine specimens
Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Interpretation
Provides information to assist in interpretation of the test results
Low glomerular filtration rate (GFR) values indicate abnormal renal function, which may be either reversible/transient or irreversible/permanent. GFR tends to decline with age.
Cautions
Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
A theoretical complication to injection of iodinated contrast media (one that has not been observed clinically to date) is the transient suppression of thyroid function in premature and newborn infants. Therefore, a sensitive thyrotropin test is suggested approximately 2 to 3 weeks after an iohexol clearance in that age group.
Clinical Reference
Recommendations for in-depth reading of a clinical nature
1. Brown SC, O'Reilly PH: Iohexol clearance for the determination of glomerular filtration rate in clinical practice: evidence for a new gold standard. J Urol 1991;146:675-679
2. Gaspari F, Perico N, Ruggenenti P, et al: Plasma clearance of nonradioactive iohexol as a measure of glomerular filtration rate. J Am Soc Nephrol 1995;6:257-263
3. Schwartz GJ, Abraham AG, Furth SL, et al: Optimizing iohexol plasma disappearance curves to measure the glomerular filtration rate in children with chronic kidney disease. Kidney Int 2010;77:65-71
Method Description
Describes how the test is performed and provides a method-specific reference
Timed urine specimens are obtained after subcutaneous injection of nonradiolabeled iohexol. Iohexol results are acquired via a liquid chromatography-tandem mass spectrometry (LC-MS/MS) system. A ThermoFisher LX-2 Cohesive HPLC System and an ABSciex 5500 MS/MS are used for analysis.(Seegmiller JC, Burns BE, Lieske JC, et al: Discordant glomerular filtration rate determinations between iothalamate and iohexol renal clearances. Poster Session at: Renal Week 2010. 43rd Annual Meeting of the American Society of Nephrology. Denver, CO, 2010 Nov 16-21)
PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information
No
Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.
3 to 4 days
Specimen Retention Time
Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded
7 days
Rochester
Fees
Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.
- Authorized users can sign in to Test Prices for detailed fee information.
- Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
- Prospective clients should contact their Regional Manager. For assistance, contact Customer Service.
Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.
This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.
Test Id |
Test Order Name |
Order LOINC Value
|
HEXU |
Iohexol, U |
93973-6 |
Result Id |
Test Result Name |
Result LOINC Value
Applies only to results expressed in units of measure originally reported by the performing laboratory. These values do not apply to results that are converted to other units of measure.
|
61712 |
Iohexol, U |
93973-6 |
Test Setup Resources
Setup Files
Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.
Excel |
Pdf
SI Sample Reports
International System (SI) of Unit reports are provided for a limited number of tests. These reports are intended for international account use and are only available through MayoLINK accounts that have been defined to receive them.
SI Normal Reports |
SI Abnormal Reports