Test Catalog

Test Id : CVRMA

Cardiovascular Risk Marker Panel, Serum

Useful For
Suggests clinical disorders or settings where the test may be helpful

Assessment for risk of developing cardiovascular disease, major adverse cardiovascular events, or ischemic cerebrovascular events

Profile Information
A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test Id Reporting Name Available Separately Always Performed
NHDCH Non HDL Cholesterol No Yes
CLDL Calculated LDL No Yes
HDCH Cholesterol, HDL, S Yes Yes
CHOL Cholesterol, Total, S Yes Yes
TRIG Triglycerides, S Yes Yes
CVINT Interpretation No Yes
LIPA1 Lipoprotein(a), S Yes Yes
HSCRP C-Reactive Protein, High Sens, S Yes Yes
APOLB Apolipoprotein B, S Yes Yes

Method Name
A short description of the method used to perform the test

LIPA1, HSCRP, APOLB: Immunoturbidimetry

CHOL, TRIG, HDCH: Enzymatic Colorimetric

CLDL: Friedewald Equation

NHDCH: Calculation

NY State Available
Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name
Lists a shorter or abbreviated version of the Published Name for a test

Cardiovascular Risk Marker Panel, S

Lists additional common names for a test, as an aid in searching

Additional CV Risk Factors

Additional Risk Factors

Atherosclerosis Risk Factors CV Risk Panel

C-Reactive protein

C-reactive protein, Cardiac

Cardiac Risk Panel

Cardiovascular Risk Markers

Cardiovascular Risk Panel

Conditional CV Risk Marker Panel

Conditional Risk Markers

Coronary Risk Factors


CV Health Clinic

Emerging Risk Markers


Lipid screen

Lipoprotein (a)

New CV Risk Factors

Protein, C-Reactive

Risk Markers

Specimen Type
Describes the specimen type validated for testing


Specimen Required
Defines the optimal specimen required to perform the test and the preferred volume to complete testing

Patient Preparation:

1. Patients must be fasting for at least 12 to 14 hours.

2. Patient must not consume any alcohol for 24 hours before specimen collection.

Collection Container/Tube: 

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 2.5 mL

Collection Instructions: Centrifuge and aliquot serum into plastic vial. Send refrigerated.

Specimen Minimum Volume
Defines the amount of sample necessary to provide a clinically relevant result as determined by the Testing Laboratory

1.25 mL

Reject Due To
Identifies specimen types and conditions that may cause the specimen to be rejected

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus Reject

Specimen Stability Information
Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 7 days
Frozen 30 days

Useful For
Suggests clinical disorders or settings where the test may be helpful

Assessment for risk of developing cardiovascular disease, major adverse cardiovascular events, or ischemic cerebrovascular events

Clinical Information
Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Cardiovascular disease remains the leading cause of morbidity and mortality despite well-defined risk factors and treatment strategies. Atherosclerosis, the underlying cause of cardiovascular disease, is a buildup of plaque within arteries. This buildup of plaque can lead to chronic or acute restrictions in blood flow resulting in heart attacks and strokes. Many of these events occur in individuals with no prior symptoms. Standard risk factors include age, smoking status, hypertension, diabetes, total serum cholesterol, and high-density lipoprotein cholesterol.


Apolipoprotein B (ApoB), high-sensitivity C-reactive protein (hsCRP), and lipoprotein (a) (Lp[a]) are serological risk factors endorsed by multiple international guidelines for use in cardiovascular disease risk assessment. Several recent guidelines have suggested that clinicians utilize ApoB, hsCRP, and Lp(a) in selected persons to augment risk classification, guide intensity of risk-reduction therapy and modulate clinical judgment when making therapeutic decision.(1-3)

Reference Values
Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.


2-17 years

> or =18 years

Non-HDL cholesterol (mg/dL)


Acceptable: <120

Borderline high: 120-144

High: > or =145


Desirable: <130 mg/dL

Above Desirable: 130-159 mg/dL

Borderline high: 160-189 mg/dL

High: 190-219 mg/dL

Very high: > or =220 mg/dL

LDL cholesterol (mg/dL)


Acceptable: <110

Borderline high: 110-129

High: > or =130


Desirable: <100

Above Desirable: 100-129

Borderline high: 130-159

High: 160-189

Very high: > or =190

HDL cholesterol (mg/dL)


Low: <40

Borderline low: 40-45

Acceptable: > 45


Males: > or =40

Females: > or =50


Total cholesterol (mg/dL)


Acceptable: <170

Borderline high: 170-199

High: > or =200


Desirable: < 200

Borderline high: 200 - 239

High: > or = 240

LIPOPROTEIN (a) (nmol/L)

Not established

< 75 nmol/L

Values >= 75 nmol/L may suggest increased risk of coronary heart disease.



Lower risk: <2.0 mg/L

Higher risk: >=2.0 mg/L

Acute inflammation: >10.0 mg/L


Lower risk: <2.0 mg/L

Higher risk: >=2.0 mg/L

Acute inflammation: >10.0 mg/L

Apolipoprotein B (mg/dL)

Acceptable: <90

Borderline high: 90-109

High: > or =110

Desirable: <90

Above Desirable: 90-99

Borderline high: 100-119

High: 120-139

Very high: > or =140



2-9 years

10-17 years

> or =18 years

Triglycerides (mg/dL)


Acceptable: <75 

Borderline high: 75-99

High: > or =100


Acceptable: <90 

Borderline high: 90-129

High: > or =130


Normal: <150

Borderline high: 150-199

High: 200-499

Very high: > or =500


*National Lipid Association 2014

**Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents

***National Cholesterol Education Program (NCEP)

Provides information to assist in interpretation of the test results

Specific interpretations are provided based on lipid results according to Mayo Clinic care process models. Mayo Clinic has adopted the National Lipid Association classifications, which are included as reference values on Mayo Clinic and Mayo Clinic Laboratories reports (see Reference Values).


More aggressive treatment strategies may be pursued in patients determined to be at increased risk.

Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Lipid values should be considered in the context of clinical presentation. Additional risk factors include cigarette smoking, hypertension, age and personal or family history of cardiovascular disease.


Result can be falsely decreased in patients with elevated levels of N-acetyl-p-benzoquinone imine (NAPQI)-a metabolite of acetaminophen, N-acetylcysteine (NAC), and metamizole.

Clinical Reference
Recommendations for in-depth reading of a clinical nature

1. Jacobson TA, Ito MK, Maki KC, et al: National Lipid Association recommendations for patient-centered management of dyslipidemia: part 1 - executive summary. J Clin Lipidol. 2014 Sep-Oct;8(5):473-488

2. Perk J, DeBacker G, Gohlke H, et al: European Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2012;33:1635-1701

3. Grundy SM, Stone NJ, Bailey AL, et al: 2018. AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019 Jun 18;139(25):e1082-e1143

4. Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents; National Heart, Lung, and Blood Institute: Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents. Pediatrics. 2011;128;S213-S256

Method Description
Describes how the test is performed and provides a method-specific reference

The following calculations are performed in the laboratory information system, SCC Soft.

Non-high-density lipoprotein (HDL) cholesterol = Total cholesterol – HDL cholesterol

Low-density lipoprotein (LDL) cholesterol = Total cholesterol - HDL cholesterol - (Triglycerides/5)


HDL Cholesterol:

Non-HDL lipoproteins such as LDL, very low-density lipoprotein (VLDL) and chylomicrons are combined with polyanions and a detergent forming a water-soluble complex. In this complex the enzymatic reaction of cholesterol esterase (CHER) and cholesterol oxidase (CHOD) towards non-HDL lipoproteins is blocked. Finally, only HDL-particles can react with CHER and CHOD. The concentration of HDL-cholesterol is determined enzymatically by CHER and CHOD. Cholesterol esters are broken down quantitatively into free cholesterol and fatty acids by CHER. In the presence of peroxidase, the hydrogen peroxide generated reacts with 4-amino-antipyrine and N-ethyl-N-(3-methylphenyl)-N'-succinylethylenediamine) to form a dye. The color intensity of this dye is directly proportional to the cholesterol concentration and is measured photometrically.(Package insert: HDL-Cholesterol Gen4. Roche Diagnostics; V 2.0, 08/2018)


Total Cholesterol:

Cholesterol esters are cleaved by the action of cholesterol esterase to yield free cholesterol and fatty acids. Cholesterol oxidase then catalyzes the oxidation of cholesterol to cholest-4-en-3-one and hydrogen peroxide. In the presence of peroxidase, the hydrogen peroxide formed effects the oxidative coupling of phenol and 4-aminophenazone to form a red quinone-imine dye. The color intensity of the dye formed is directly proportional to the cholesterol concentration. It is determined by measuring the increase in absorbance.(Package insert: Cholesterol Gen2 Reagent. Roche Diagnostics; V 10.0, 03/2020)



This test uses a lipoprotein lipase from microorganisms for the rapid and complete hydrolysis of triglycerides to glycerol followed by oxidation to dihydroxyacetone phosphate and hydrogen peroxide. The hydrogen peroxide produced then reacts with 4-aminophenazone and 4-chlorophenol under the catalytic action of peroxidase to form a red dyestuff (Trinder endpoint reaction). The color intensity of the red dyestuff formed is directly proportional to the triglyceride concentration and can be measured photometrically.(Package insert: Triglycerides. Roche Diagnostics; V 9.0, 01/2020)


Lipoprotein (a):

This test is a particle enhanced immunoturbidimetric assay. Human lipoprotein (a)(Lp[a]) agglutinates with the latex particles coated with anti-Lp(a) antibodies.(Package insert: Lipoprotein (a) Gen.2 reagent. Roche Diagnostics; V2.0, 01/2015)


C-Reactive Protein:

Particle-enhanced immunoturbidimetric assay. Human C-reactive protein (CRP) agglutinates with latex particles coated with monoclonal anti-CRP antibodies. The precipitate is determined turbidimetrically.(Package insert: Cardiac C-Reactive Protein (Latex) High Sensitive. Roche Diagnostics; V 12.0, 03/2019)


Apolipoprotein B:

Anti-apolipoprotein B antibodies react with the antigen in the sample to form antigen:antibody complexes, which, following agglutination, can be measured turbidimetrically.(Package insert: Tina-quant Apolipoprotein B, Roche Diagnostics; V1.0 07/2020)

PDF Report
Indicates whether the report includes an additional document with charts, images or other enriched information


Day(s) Performed
Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.

Monday through Sunday

Report Available
The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.

1 to 2 days

Specimen Retention Time
Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded

7 days

Performing Laboratory Location
Indicates the location of the laboratory that performs the test


Several factors determine the fee charged to perform a test. Contact your U.S. or International Regional Manager for information about establishing a fee schedule or to learn more about resources to optimize test selection.

  • Authorized users can sign in to Test Prices for detailed fee information.
  • Clients without access to Test Prices can contact Customer Service 24 hours a day, seven days a week.
  • Prospective clients should contact their Regional Manager. For assistance, contact Customer Service.

Test Classification
Provides information regarding the medical device classification for laboratory test kits and reagents. Tests may be classified as cleared or approved by the US Food and Drug Administration (FDA) and used per manufacturer instructions, or as products that do not undergo full FDA review and approval, and are then labeled as an Analyte Specific Reagent (ASR) product.

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information
Provides guidance in determining the appropriate Current Procedural Terminology (CPT) code(s) information for each test or profile. The listed CPT codes reflect Mayo Clinic Laboratories interpretation of CPT coding requirements. It is the responsibility of each laboratory to determine correct CPT codes to use for billing.

CPT codes are provided by the performing laboratory.

80061-Lipid panel (includes: HDL [CPT Code 83718], total cholesterol [CPT Code 82465], and triglycerides [CPT Code 84478])

83695-Lipoprotein (a)

86141-C-reactive protein; high sensitivity (hsCRP)

82172-Apolipoprotein B

Test Setup Resources

Setup Files
Test setup information contains test file definition details to support order and result interfacing between Mayo Clinic Laboratories and your Laboratory Information System.

Excel | Pdf

Sample Reports
Normal and Abnormal sample reports are provided as references for report appearance.

Normal Reports | Abnormal Reports

SI Sample Reports
International System (SI) of Unit reports are provided for a limited number of tests. These reports are intended for international account use and are only available through MayoLINK accounts that have been defined to receive them.

SI Normal Reports | SI Abnormal Reports