Test ID: TP53Z    
TP53 Gene, Li Fraumeni Syndrome, Full Gene Analysis, Varies

When this test is ordered, comparative genomic hybridization array will always be performed at an additional charge.

See TP53 Mutation Testing Analysis in Special Instructions.

This test is not appropriate for evaluation of somatic TP53 mutations. To evaluate for the presence of somatic TP53 mutations for diagnostic or prognostic purposes in patients with chronic lymphocytic leukemia, see P53CA / Hematologic Neoplasms, TP53 Somatic Mutation, DNA Sequencing Exons 4-9.

Specimen preferred to arrive within 96 hours of draw.

Patient Preparation: A previous bone marrow transplant from an allogenic donor will interfere with testing. Call 800-533-1710 for instructions for testing patients who have received a bone marrow transplant.

Specimen Type: Whole blood

Container/Tube:

Preferred: Lavender top (EDTA) or yellow top (ACD)

Acceptable: Any anticoagulant

Specimen Volume: 3 mL

Collection Instructions:

1. Invert several times to mix blood.

2. Send specimen in original tube.

• Molecular Genetics: Inherited Cancer Syndromes Patient Information
• Informed Consent for Genetic Testing
• TP53 Mutation Testing Algorithm
• Informed Consent for Genetic Testing (Spanish)

1. New York Clients-Informed consent is required. Document on the request form or electronic order that a copy is on file. The following documents are available in Special Instructions:

-Informed Consent for Genetic Testing (T576)

-Informed Consent for Genetic Testing-Spanish (T826)

2. Molecular Genetics: Inherited Cancer Syndromes Patient Information (T519) in Special Instructions

All specimens will be evaluated by Mayo Clinic Laboratories for test suitability.