TEST CATALOG ORDERING & RESULTS SPECIMEN HANDLING CUSTOMER SERVICE EDUCATION & INSIGHTS
Test Catalog

Test ID: PDG12    
PDGFRA Exon 12, Mutation Analysis

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

This test is performed in conjunction with SLIRV / Slide Review in MG. Additional testing may be performed after review by pathologist. Upon approval from the requesting clinician, PATHC / Pathology Consultation may be added, if appropriate.

Specimen Type Describes the specimen type validated for testing

Varies

Advisory Information

This is not appropriate for evaluation of hypereosinophilic syndrome (HES) and systemic mast cell disease involving the FIP1L1-PDGFRA fusion. If that evaluation is desired, order CHICF / CHIC2 (4q12) Deletion (FIP1L1 and PDGFRA Fusion), FISH.

 

Special stains performed outside Mayo Clinic Laboratories and included with the case may be repeated and charged at the reviewing pathologist's discretion. Testing requested by referring physician may not be performed if deemed unnecessary by Mayo Clinic pathologist.

Necessary Information

Specimen Required Defines the optimal specimen required to perform the test and the preferred volume to complete testing

A quality specimen is essential for evaluation. Submit only tissue containing tumor cells; minimal tissue is required for evaluation.

 

Bone marrow aspirate (in EDTA) and specimens that have been decalcified are not appropriate specimens for this test. If these are received, testing will be canceled.

 

Supplies: Surgical Pathology Packaging Kit (T554) requested, but not required

 

Preferred:

Specimen Type: Formalin-fixed, paraffin-embedded (FFPE) tissue block with a minimum of 60% tumor cell population

Collection Instructions: Process all specimens into FFPE tissue blocks prior to submission.

 

Acceptable:

Specimen Type: Unstained slides with a minimum of 60% tumor population; slides may be stained and/or scraped.

Slides: A minimum of ten, 4- to 5-micron thick, unstained slides are required.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Forms

1. Pathology/Cytology Information (T707) in Special Instructions

2. If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.

Reject Due To Identifies specimen types and conditions that may cause the specimen to be rejected

Tissue Specimens that have been decalcified (all methods); specimens that have not been formalin-fixed, paraffin-embedded

Specimen Stability Information Provides a description of the temperatures required to transport a specimen to the performing laboratory, alternate acceptable temperatures are also included

Specimen TypeTemperatureTimeSpecial Container
VariesAmbient (preferred)
 Frozen 
 Refrigerated