Web: | mayocliniclabs.com |
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Email: | mcl@mayo.edu |
Telephone: | 800-533-1710 |
International: | +1 855-379-3115 |
Values are valid only on day of printing. |
This test includes a charge for application of the first probe set (2 FISH probes) and professional interpretation of results. Additional charges will be incurred for all reflex probes performed. Analysis charges will be incurred based on the number of cells analyzed per probe set. If no cells are available for analysis, no analysis charges will be incurred.
When this test and flow cytometry testing for leukemia/lymphoma are ordered concurrently, the flow cytometry result will be utilized to determine if sufficient clonal T-cells are available for FISH testing. If the result does not identify a sufficient clonal T-cell population, this FISH test order will be canceled and no charges will be incurred.
If FISH testing proceeds, probes will be performed based on the lymphoma subtype suspected/identified utilizing the table located in Clinical Information.
If the patient is being tracked for known abnormalities, indicate which probes should be used.
The following probe sets are available within the T-cell lymphoma FISH profile:
14q32.1 rearrangement, TCL1A
/i(7q)/ -7/7q-, D7S486/D7Z1
+8, D8Z2/MYC
If T-cell prolymphocytic leukemia/lymphoma (T-PLL) is indicated, TCL1A rearrangement is performed, with reflex to the TRAD FISH probe if TCL1A is negative,
See Bone Marrow Staging for Known or Suspected Malignant Lymphoma Algorithm in Special Instructions.
This assay detects chromosome abnormalities observed in the blood or bone marrow of patients with T-cell lymphoma.
-For testing paraffin-embedded tissue samples from patients with T-cell lymphoma, see TLYM / T-Cell Lymphoma, FISH, Tissue.
-For patients with T-cell acute lymphoblastic leukemia/lymphoma, order TALLF / T-Cell Acute Lymphoblastic Leukemia [T-ALL], FISH, Varies.
Advise Express Mail or equivalent if not on courier service.
1. Provide a reason for referral with each specimen. The laboratory will not reject testing if this information is not provided, but appropriate testing and interpretation may be compromised or delayed.
2. A pathology or flow cytometry report may be requested by the Genomics Laboratory to optimize testing and aid in interpretation of results.
Submit only 1 of the following specimens:
Preferred:
Specimen Type: Bone marrow
Container/Tube: Green top (sodium heparin)
Specimen Volume: 1-2 mL
Collection Instructions: Invert several times to mix bone marrow.
Acceptable:
Specimen Type: Blood
Container/Tube: Green top (sodium heparin)
Specimen Volume: 7-10 mL
Collection Instructions: Invert several times to mix blood.
If not ordering electronically, complete, print, and send a Hematopathology/Cytogenetics Test Request (T726) with the specimen.
Specimen Type | Temperature | Time | Special Container |
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Varies | Ambient (preferred) | ||
Refrigerated |