TEST CATALOG ORDERING & RESULTS SPECIMEN HANDLING CUSTOMER SERVICE EDUCATION & INSIGHTS
Test Catalog

Test ID: MGT1    
Myasthenia Gravis (MG) Evaluation, Thymoma, Serum

Method Description Describes how the test is performed and provides a method-specific reference

Muscle acetylcholine receptor (AChR) binding (IgG and IgM) are quantitated by immunoprecipitation assays. Fetal and adult, detergent-solubilized, acetylcholine receptors (extracted from cultures of rhabdomyosarcoma [RD] cells) labeled with (125)I-alpha-bungarotoxin are incubated with patient serum. AChR modulating antibody is detected in a bioassay: following 14-hour incubation with patient's serum, viable, noninnervated, monolayer cultures of human muscle cells are probed with (125)I-bungarotoxin to quantitate percent loss of surface AChR. Striational antibodies (IgG, IgM, and IgA) are detected by EIA using as antigen a mixture of sarcomeric proteins extracted from healthy adult rat skeletal muscle.(Griesmann GE, Kryzer TJ, Lennon, VA: Autoantibody profiles of myasthenia gravis and Lambert-Eaton myasthenic syndrome. In Manual of Clinical and Laboratory Immunology. Sixth edition. Edited by NR Rose, RG Hamilton, B Detrick, Washington, DC, ASM Press, 2002, pp 1005-1012)

 

CRMP-5-IgG is detected by Western blot assay using recombinant human collapsin response-mediator protein-5 as antigen.(Yu Z, Kryzer TJ, Griesmann GE, et al: CRMP-5 neuronal autoantibody: marker of lung cancer and thymoma-related autoimmunity. Ann Neurol 2001 February;49[2]:146-154)

PDF Report Indicates whether the report includes an additional document with charts, images or other enriched information

No

Day(s) and Time(s) Test Performed Outlines the days and times the test is performed. This field reflects the day and time the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time required before the test is performed. Some tests are listed as continuously performed, which means assays are performed several times during the day.

ACh receptor (muscle) binding antibody:

Monday through Friday; 11 a.m., 6 p.m., 10 p.m.

Saturday; 6 a.m.

Sunday; 6 a.m., 10 a.m.

 

ACh receptor (muscle) modulating antibodies:

Monday through Thursday; 2 p.m.

Saturday; 8 a.m.

 

Striational (striated muscle) antibodies:

Monday through Friday; 4 a.m., 3 p.m.

Saturday; 6 a.m.

 

CRMP-5-IgG Western blot:

Monday, Wednesday, Friday; 8 a.m.

 

AChR ganglionic neuronal antibody:

Monday through Friday; 11 a.m., 6 p.m.

Saturday; 6 a.m.

Sunday; 6 a.m.

 

Neuronal (V-G) K+ channel autoantibody:

Monday through Friday; 11 a.m., 6 p.m.

Saturday; 6 a.m.

Sunday; 6 a.m.

 

GAD65 antibody assay:

Monday through Friday; 6 a.m., 4 p.m.

Analytic Time Defines the amount of time it takes the laboratory to setup and perform the test. This is defined in number of days. The shortest interval of time expressed is "same day/1 day," which means the results may be available the same day that the sample is received in the testing laboratory. One day means results are available 1 day after the sample is received in the laboratory.

3 days

Maximum Laboratory Time Defines the maximum time from specimen receipt at Mayo Clinic Laboratories until the release of the test result

7 days

Performing Laboratory Location Indicates the location of the laboratory that performs the test

Rochester