Test Catalog

Test ID: SEQA    
Sequential Maternal Screening, Part 1, Serum

Method Description Describes how the test is performed and provides a method-specific reference

This test includes measuring the nuchal translucency (NT) and pregnancy-associated plasma protein A (PAPP-A). The NT and PAPP-A are compared to median values for a given gestational age and a multiple-of-the-median (MoM) is calculated for each. The MoM results are entered into a multivariate algorithm that includes the mother's age to derive risk factors for Down syndrome and trisomy 18. If the calculated risks exceed the screen cutoff, the results are reported and the screen is ended. If the results from the first part of screening fall below the screen cutoff, the results are held until the second sample is analyzed. PAPP-A is performed on the Beckman Access using an automated immunoenzymatic assay with paramagnetic separation and chemiluminescent detection.(Package insert: PAPP-A, Beckman-Coulter Access, 2019)

PDF Report Indicates whether the report includes an additional document with charts, images or other enriched information


Day(s) Performed Outlines the days the test is performed. This field reflects the day that the sample must be in the testing laboratory to begin the testing process and includes any specimen preparation and processing time before the test is performed. Some tests are listed as continuously performed, which means that assays are performed multiple times during the day.

Monday through Friday

Report Available The interval of time (receipt of sample at Mayo Clinic Laboratories to results available) taking into account standard setup days and weekends. The first day is the time that it typically takes for a result to be available. The last day is the time it might take, accounting for any necessary repeated testing.

1 to 3 days

Specimen Retention Time Outlines the length of time after testing that a specimen is kept in the laboratory before it is discarded

9 months

Performing Laboratory Location Indicates the location of the laboratory that performs the test