Test Catalog

Test ID: MPSSC    
Mucopolysaccharides (MPS) Screen, Urine

Useful For Suggests clinical disorders or settings where the test may be helpful

Preferred screening test for mucopolysaccharidoses

Genetics Test Information Provides information that may help with selection of the correct genetic test or proper submission of the test request

Preferred test to screen for mucopolysaccharidosis (MPS). Testing includes both quantitative and qualitative MPS analysis.


The urine mucopolysaccharides (MPS) screen is the preferred first-line screening test that provides quantitative analysis of total glycosaminoglycans (GAG) and qualitative liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of the specific sulfates that are associated with at least 13 different diseases.


An abnormal total GAG value may be obtained on a specimen that yields a normal LC-MS/MS pattern, and this artifact can occur when a patient is treated with low-molecular-weight heparin.

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
MPSQNMucopolysaccharides (MPS), QN, UYesYes
MPSQLMucopolysaccharides, (MPS), QL, UNoYes

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

See Newborn Screen Follow-up for Mucopolysaccharidosis Type I in Special Instructions.


For more information, see Newborn Screening Act Sheet Mucopolysaccharidosis Type I: Decreased Alpha-L-Iduronidase in Special Instructions.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

MPSQL: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

MPSQN: Spectrophotometry (SP)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Mucopolysaccharides Screen, (MPS),U

Aliases Lists additional common names for a test, as an aid in searching

Arylsulfatase B Deficiency
Berry Spot
Beta-Galactosidase Deficiency
Beta-Glucoronidase Deficiency
Chondroitin Sulfate
Dermatan Sulfate
GAGS (Glycosaminoglycans)
Galactose-6-Sulfatase Deficiency
Glycosaminoglycans (GAGS)
Heparan Sulfate
Hunter Syndrome
Hurler Syndrome
Hurler/Scheie Syndrome
Iduronate Sulfatase Deficiency
Iduronidase Deficiency
Keratan Sulfate
Lysosomal Storage Disease
Maroteaux Lamy Syndrome
Maroteaux-Lamy Syndrome
Morquio A
Morquio B
Multiple Sulfatase Deficiency
Sanfilippo Syndrome
Scheie Syndrome
Sly Syndrome
Lysosomal Storage