Test Catalog

Test ID: MEVP    
Methemoglobinemia Evaluation

Useful For Suggests clinical disorders or settings where the test may be helpful

Diagnosis of methemoglobinemia and sulfhemoglobinemia and possible hereditary (congenital) causes


Differentiation of methemoglobinemia and sulfhemoglobinemia from other causes of cyanosis (eg, congenital heart disease)

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
MEVMethemoglobinemia InterpretationNoYes
A2FHemoglobin A2 and FNoYes
HBELHemoglobin Electrophoresis, BNoYes
METHMethemoglobin, BYes, (Order MET)Yes
SULFSulfhemoglobin, BYes, (Order MET)Yes
METRMethemoglobin Reductase, BYesYes

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
SDEXHemoglobin S, Scrn, BYesNo
IEFIEF ConfirmsNoNo
MASSHb Variant by Mass Spec, BNoNo
UNHBUnstable Hemoglobin, BNoNo
HPFHHemoglobin F, Red Cell Distrib, BNoNo
ATHALAlpha-Globin Gene AnalysisYesNo
WASQRAlpha Globin Gene Sequencing, BYes, (Order WASEQ)No
WBSQRBeta Globin Gene Sequencing, BYes, (Order WBSEQ)No
WBDDRBeta Globin Cluster Locus Del/Dup,BYes, (Order WBDD)No
MEVAMethemoglobin Summary InterpNoNo
WGSQRGamma Globin Full Gene SequencingNoNo

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

This is a consultative evaluation in which the case will be evaluated at Mayo Clinic Laboratories, the appropriate tests performed at an additional charge, and the results interpreted. This is an evaluation for methemoglobin and sulfhemoglobin levels and possible hereditary causes. Methemoglobin, sulfhemoglobin levels, methemoglobin reductase (cytochrome-b5 reductase) activity and protein analysis screening for hemoglobin variants (cation exchange HPLC and capillary electrophoresis) will always be performed. If additional hemoglobin variant confirmatory testing is required, appropriate reflex testing will be performed. This will vary from additional protein analysis methods to molecular testing, as needed.


MEVA / Methemoglobin Summary Interpretation, an additional consultative interpretation that summarizes all testing, will be provided after additional testing is completed if any of the following molecular tests are reflexed on the MEVP / Methemoglobinemia Evaluation:

-ATHAL / Alpha-Globin Gene Analysis

-WASQR / Alpha-Globin Gene Sequencing, Blood

-WBSQR / Beta-Globin Gene Sequencing, Blood

-WBDDR / Beta-Globin Cluster Locus Deletion/Duplication, Blood

-WGSQR / Gamma-Globin Full Gene Sequencing


See Benign Hematology Evaluation Comparison in Special Instructions.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

MEV: Consultative Interpretation

A2F: Cation Exchange/High-Performance Liquid Chromatography (HPLC)

HBEL: Capillary Electrophoresis

METH, SULF: Spectrophotometry (SP)

METR: Kinetic Spectrophotometry (KS)

MASS: Mass Spectrometry (MS)

IEF: Electrophoresis

HPFH: Flow Cytometry

UNHB: Isopropanol and Heat Stability

MEVA: Consultative Interpretation

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Methemoglobinemia Evaluation

Aliases Lists additional common names for a test, as an aid in searching

Hemoglobin M
Methemoglobin Evaluation
M Hemoglobins
NADH methemoglobin reductase deficiency
NADH cytochrome b5 reductase 3
cytochrome b5 reductase deficiency
Congenital methemoglobinemia
Recessive congenital methemoglobinemia
Dominant congenital methemoglobinemia
Congenital methaemoglobinemia
Cb5r deficiency