TEST CATALOG ORDERING & RESULTS SPECIMEN HANDLING CUSTOMER SERVICE EDUCATION & INSIGHTS
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Test ID: PSYGP    
Psychotropic Pharmacogenomics Gene Panel, Varies

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Useful For Suggests clinical disorders or settings where the test may be helpful

Individualizing selection and dosage of medications prescribed for treatment of depression and other psychiatric disorders based on genetic variation

 

Identifying genetic variation in genes known to be associated with response and/or risk of toxicity with psychotropic medications

 

Evaluating patients who have failed therapy with selective serotonin reuptake inhibitors (SSRIs)

 

Evaluating patients with treatment-resistant depression

 

Predicting response time to improvement with SSRIs

Genetics Test Information Provides information that may help with selection of the correct genetic test or proper submission of the test request

This test includes targeted testing to evaluate the following genes: ANKK1, ADRA2, CHRNA3, COMT, CYP1A2, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, DRD2, EPHX1, GRIK4, HLA-A*31:01, HLA-B*15:02, HTR2A, HTR2C, MTHFR, OPRM1, SCN1A, SLC6A4 (5-HTT), UGT2B15.

 

CYP2D6 testing is done in 2 tiers when needed. Tier 1 uses a PCR-based 5'-nuclease assay to determine the variants present. All samples also have copy number determined by PCR-based 5'-nuclease assay. Testing in tier 1 allows for the detection of all common CYP2D6 variants (eg, *2, *3, *4, *5, *6, *7, *8, *9, *10, *17, *29, *35, *41) and rarer alleles such as *11, *12, *14A, *14B, and *15. Duplications and multiplications of alleles are also identified. Unitary and tandem CYP2D7-2D6 (*13) alleles and CYP2D6-2D7 (eg, *4N, *36, and *68) alleles can also be detected. Tier 2 testing involves sequencing using fluorescent dye-terminator chemistry and is only done if an ambiguous phenotype results from tier 1 testing. Approximately 3% of samples require tier 2 testing.

 

Prior Authorization is available for this assay; see Special Instructions.

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
2D6S1CYP2D6 FULL GENE SEQUENCENo, (Bill Only)No
2D6S2CYP2D6 GEN CYP2D6-2D7 HYBRIDNo, (Bill Only)No
2D6S3CYP2D6 GEN CYP2D7-2D6 HYBRIDNo, (Bill Only)No
2D6S4CYP2D6 NONDUPLICATED GENENo, (Bill Only)No
2D6S5CYP2D6 5' GENE DUP/MLTNo, (Bill Only)No
2D6S6CYP2D6 3' GENE DUP/MLTNo, (Bill Only)No

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

If a specimen requires follow-up for CYP2D6, then reflex testing will be performed as appropriate at an additional charge.

 

See CYP2D6 Comprehensive Cascade Testing Algorithm in Special Instructions.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

Real-Time Polymerase Chain Reaction (RT-PCR) with Allelic Discrimination Analysis

 

Qualitative Allele-Specific Real-Time Polymerase Chain Reaction (PCR)

 

PCR Followed by Sizing Analysis

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Psychotropic PGx Panel

Aliases Lists additional common names for a test, as an aid in searching

Pharmacogenetic panel
Psychiatry Pharmacogenomic Panel
Psychiatric Pharmacogenomic Panel
Psychotropic Pharmacogenetic Panel
Cytochrome P450
Gene Panel
P450 Genotype
P450 Genotyping
PGx Panel
PGx
Pre-emptive genotyping
Antidepressant failure
Antidepressant panel
Antipsychotic panel
Antianxiety panel
Mood stabilizer panel
Depression panel
Selection of right medication
ANKK1
ADRA2
CHRNA3
COMT
CYP1A2
CYP2B6
CYP2C9
CYP2C19
CYP2D6
CYP3A4
CYP3A5
DRD2
EPHX1
GRIK4
HLA-A*31:01
HLA-B*15:02
HTR2A
HTR2C
MTHFR
OPRM1
SCN1A
SLC6A4 (5-HTT)
UGT2B15