Test Catalog

Test ID: HPGP    
Hereditary Pheochromocytoma/Paraganglioma Multi Gene Panel

Useful For Suggests clinical disorders or settings where the test may be helpful

Providing a comprehensive evaluation for paraganglioma/pheochromocytoma in patients with a personal or family history suggestive of a hereditary paraganglioma/pheochromocytoma syndrome

 

Serving as a second-tier test for patients in whom previous targeted gene variant analyses for specific hereditary paraganglioma/pheochromocytoma-related genes were negative

 

Establishing a diagnosis of a hereditary paraganglioma/pheochromocytoma syndrome in some cases, allowing for targeted cancer surveillance of associated tissues and organs known to be at increased risk for tumor or cancer

 

Identifying variants within genes known to be associated with increased risk for paraganglioma/pheochromocytoma allowing for predictive testing of at-risk family members

Genetics Test Information Provides information that may help with selection of the correct genetic test or proper submission of the test request

This test includes next-generation sequencing and multiplex ligation-dependent probe amplification to evaluate for the genes listed on the panel.

 

Sanger sequencing may also be performed to confirm detected variants.

 

The RET gene is not included in the multiplex ligation-dependent probe amplification (MLPA) portion of the test.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

Long-range PCR amplification of targeted genes followed by next-generation sequencing and gene dosage analysis by multiplex ligation-dependent probe amplification (MLPA). Confirmations are performed using polymerase chain reaction (PCR) and Sanger sequencing.

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Hereditary Pheo/Paraganglioma Panel

Aliases Lists additional common names for a test, as an aid in searching

MAX
RET
SDHAF2
SDHB
SDHC
SDHD
TMEM127
VHL
Pheochromocytoma
Pheo
Paraganglioma
PCC
PGL
HPGP
Hereditary Cancer Panel
Next Gen Sequencing Test
Targeted Gene Panel