Referred Tests
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| Email: | mcl@mayo.edu |
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Test ID: ELYME
Lyme Disease European Antibody Screen, Serum
Useful For 
Suggests clinical disorders or settings where the test may be helpful
Aiding in the diagnosis of Lyme disease caused by infection with Borrelia species endemic to Europe and Asia, including Borrelia garinii and Borrelia afzelii
This test should not be used to screen the general population. It is only intended for use in patients with recent travel to and exposure to ticks in Europe or regions of Asia who are suspected to have Lyme disease caused by Borrelia species endemic to Europe/Asia.
Highlights
The first-tier screening assay detects antibodies to the VlsE protein. C6 is a conserved epitope in the VlsE protein. Therefore, this assay will detect antibodies to C6, in addition to other epitopes on VlsE and pepC10.
This test should be ordered for evaluation of possible Lyme disease in individuals who have recently traveled to Europe or Asia and who have been exposed to or bitten by a tick.
This panel includes a screening test capable of detecting antibodies to the most common Lyme disease causing Borrelia species found in Europe and Asia. Specimens with positive or equivocal results by the screening assay will be reflexed to a supplemental immunoblot able to detect antibodies to Borrelia afzelii or Borellia garinii, both Lyme disease-causing Borrelia species endemic to Europe and regions of Asia.
The immunoblot does not distinguish between infection with B afzelli or B garinii.
Patients infected with B afzelii or B garinii may be serologically negative by diagnostic assays used in North America, which are designed to detect antibodies to the Borrelia burgdorferi B31 strain.
Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| ELYMI | Lyme Disease European Immunoblot, S | No | No |
Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
If this test is positive or equivocal, then immunoblot testing will be performed at an additional charge.
See Acute Tick-Borne Disease Testing Algorithm in Special Instructions.
Special Instructions Library of PDFs including pertinent information and forms related to the test
Method Name A short description of the method used to perform the test
Enzyme-Linked Immunosorbent Assay (ELISA)