Referred Tests
| Web: | mayocliniclabs.com |
|---|---|
| Email: | mcl@mayo.edu |
| Telephone: | 800-533-1710 |
| International: | +1 855-379-3115 |
| Values are valid only on day of printing. | |
Test ID: F2NGS
F2 Gene, Next-Generation Sequencing, Varies
Useful For 
Suggests clinical disorders or settings where the test may be helpful
Ascertaining a causative alteration in F2 and the affected region of prothrombin protein in an individual clinically diagnosed with factor II deficiency
Carrier testing for close family members of an individual with a factor II deficiency diagnosis
This test is not intended for prenatal diagnosis.
Genetics Test Information Provides information that may help with selection of the correct genetic test or proper submission of the test request
This test detects pathogenic alterations in the F2 gene to delineate the underlying molecular defect in a patient with a laboratory diagnosis of factor II (prothrombin) deficiency (F2D).
The gene target for this test is:
Gene name (transcript): F2 (GRCh37 [hg19] NM_000506)
Chromosomal location: 11p11.2
Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.
The clinical workup for factor II deficiency (F2D) begins with special coagulation testing for factor II. See F_2 / Coagulation Factor II Activity Assay, Plasma.
Genetic testing for F2D is indicated if:
-Prothrombin (factor II) activity is reduced (less than 80% of normal)
-Acquired causes of factor II deficiency have been excluded (eg, vitamin K deficiency, warfarin anticoagulation use, liver disease, etc)
Prothrombin antigen testing, to distinguish between type I and type II deficiencies, may be helpful in cases where genetic testing results yield variants of uncertain significance.
Special Instructions Library of PDFs including pertinent information and forms related to the test
Method Name A short description of the method used to perform the test
Custom Sequence Capture and Targeted Next-Generation Sequencing (NGS) followed by Polymerase Chain Reaction (PCR) and Sanger Sequencing when appropriate
NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.
Reporting Name Lists a shorter or abbreviated version of the Published Name for a test
Aliases Lists additional common names for a test, as an aid in searching
F2D
Congenital prothrombin deficiency
Hypoprothrombinemia
Dysprothrombinemia
F2