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Test ID: LYNCH    
Lynch Syndrome Panel, Varies

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Useful For Suggests clinical disorders or settings where the test may be helpful

Establishing a diagnosis of Lynch syndrome

 

Identification of familial MLH1, MSH2, MSH6, PMS2, or EPCAM mutations to allow for predictive testing in family members

Genetics Test Information Provides information that may help with selection of the correct genetic test or proper submission of the test request

This test includes next-generation sequencing, Sanger sequencing, array comparative genomic hybridization, and multiplex ligation-dependent probe amplification to evaluate for mutations and large deletions/duplications in the MLH1, MSH2, MSH6, PMS2, and EPCAM genes. Sanger sequencing may also be performed to confirm detected variants.

 

Prior Authorization is available for this assay; see Special Instructions.

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

See Lynch Syndrome Testing Algorithm in Special Instructions.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

Custom Sequence Capture and Targeted Next Generation Sequencing Followed by Polymerase Chain Reaction (PCR) and Sanger Sequencing and Gene Dosage Analysis by Array Comparative Genomic Hybridization (aCGH) or Multiplex Ligation-Dependent Probe Amplification (MLPA)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Lynch Syndrome Panel

Aliases Lists additional common names for a test, as an aid in searching

Colon Cancer Panel
Colorectal Cancer
EPCAM
Hereditary Cancer Panel
Hereditary Colon Cancer
HNPCC
Juvenile Polyposis syndrome
Lynch syndrome
MLH1
MSH2
MSH6
Next Generation Sequencing
PMS2
Targeted Gene Panel