Web: | mayocliniclabs.com |
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Email: | mcl@mayo.edu |
Telephone: | 800-533-1710 |
International: | +1 855-379-3115 |
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Distinguish between persistent infection with the same viral strain and re-infection with a new viral strain in an individual with recurrent positive molecular test results for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Detection and identification of vaccine-escape SARS-CoV-2 variants with spike (S) gene mutations of interest
Detection and identification of SARS-CoV-2 variants containing S gene mutations of interest that reduce the efficacy of vaccine-induced antibodies, convalescent plasma, and/or monoclonal antibody therapy for COVID-19
This test uses polymerase chain reaction (PCR) to amplify multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genetic sequences covering 99.9% of the viral genome, followed by a next-generation sequencing assay with sequence analyses to determine the Pangolin lineage, NextClade clade assignment, and alterations of the viral spike (S) protein-encoding codons in known SARS-CoV-2 RNA-positive respiratory tract specimens. Testing is more likely to be successful in positive specimens with viral target cycle threshold (Ct) values of less than or equal to 30.0.
Reverse Transcription Polymerase Chain Reaction (RT-PCR) followed by Next-Generation Sequencing