TEST CATALOG ORDERING & RESULTS SPECIMEN HANDLING CUSTOMER SERVICE EDUCATION & INSIGHTS
Test Catalog

Test ID: TFGFR    
FGFR Mutation and Fusion Analysis, Tumor

Useful For Suggests clinical disorders or settings where the test may be helpful

Identification of urothelial tumors that may respond to FGFR-targeted therapies

 

This test is not intended for use for hematological malignancies and does not assess germline alterations within the genes listed.

Genetics Test Information Provides information that may help with selection of the correct genetic test or proper submission of the test request

This test is an FDA-approved assay for the evaluation of somatic mutations and fusions in the FGFR3 and FGFR2 genes to identify urothelial carcinoma patients that may be eligible for treatment with FGFR-targeted therapies such as Balversa (erdafitinib).

 

This test uses targeted reverse transcriptase (RT)-PCR to evaluate for somatic mutations within the FGFR3 gene: R248C, S249C, G370C, and Y373C. RT-PCR is also used to identify certain rearrangements (fusions): FGFR3-TACC3v3 and FGFR3-TACC3v1. Furthermore, this test can identify fusions: FGFR3-BAIAP2L1, FGFR2-BICC1, and FGFR2-CASP7, however detection of these fusions is considered off-label use of the test. For more information see Clinical Information.

 

Of note, this test is performed to evaluate for somatic mutations and rearrangements (fusions) within solid tumor samples. This test is not intended for use for hematological malignancies. Additionally, this test does not assess for germline alterations within the genes listed.

Additional Tests Lists tests that are always performed, at an additional charge, with the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
SLIRVSlide Review in MGNoYes

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

When this test is ordered, slide review will always be performed at an additional charge.

Method Name A short description of the method used to perform the test

Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

FGFR Mutation/Fusion Analysis Tumor

Aliases Lists additional common names for a test, as an aid in searching

Fibroblast growth factor receptor
FGFR Mutation
FGFR Fusion
FGFR Companion Diagnostics
Urothelial cancer
Urothelial tumor
Urothelial
Bladder cancer
Bladder tumor
Bladder
Reverse transcriptase polymerase chain reaction
RT PCR
RT-PCR
FGFR3
FGFR2
R248C
S249C
G370C
Y373C
FGFR3-TACC3v1
FGFR3-TACC3v3
FGFR3-BAIAP2L1
FGFR2-BICC1
FGFR2-CASP7
FGFR
Therascreen