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Test ID: TBNGS    
Mycobacterium tuberculosis Complex, Molecular Detection of Drug Resistance Markers, Whole Genome Sequencing, Varies

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Useful For Suggests clinical disorders or settings where the test may be helpful

Molecular detection of drug resistance variants in culture isolates of the Mycobacterium tuberculosis complex

 

May provide a more rapid detection of drug resistance than phenotypic, broth-based testing

 

Aiding in the resolution of discrepant results obtained using phenotypic methods testing for M tuberculosis isolates that are not sufficiently viable to allow for culture-based testing

Highlights

This assay may provide results within 1 week as opposed to phenotypic broth-based or agar-based assays that can take, on average, 14 days to produce results. Additionally, this assay can be useful as an aid in the resolution of discrepant phenotypic results or in instances when the isolate does not grow sufficiently well to allow for phenotypic testing.

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

Whole genome sequencing (WGS) of Mycobacterium tuberculosis complex isolates is performed followed by evaluation of selected genes of interest for the presence of well-characterized, drug resistance-conferring variants.

 

Traditional broth-based, phenotypic drug resistance testing should also be performed, since not all genes associated with resistance within the M tuberculosis complex genome have been fully elucidated or are evaluated in this test. If traditional broth-based phenotypic drug resistance testing is desired, add TB1LN / Antimicrobial Susceptibility, Mycobacterium tuberculosis Complex, First Line, Varies; TB2LN / Susceptibility, Mycobacterium tuberculosis Complex, Second Line, Varies; and TBPZA / Susceptibility, Mycobacterium tuberculosis Complex, Pyrazinamide, Varies.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

Whole Genome Sequencing

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Susceptibility, Mtb Complex, NGS

Aliases Lists additional common names for a test, as an aid in searching

Next Gen Sequencing Test
Mycobacterium tuberculosis Drug Susceptibility Test
Whole Genome Sequencing Test