Test Catalog

Test ID: SYPHT    
Syphilis Total Antibody with Reflex, Serum

Useful For Suggests clinical disorders or settings where the test may be helpful

Aiding in the diagnosis of recent or past Treponema pallidum infection


Routine prenatal screening


This test is not offered as a screening or confirmatory test for blood donor specimens.


This test is not useful for diagnosis of congenital syphilis.


This testing should be used to assess for recent or past infection with Treponema pallidum or for routine prenatal screening.


Syphilis screening at Mayo Clinic and Mayo Clinic Laboratories is performed using the reverse screening algorithm.

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
RPRSRPR Screen w/ Reflex, SNoNo
RTPPASyphilis Ab, TP-PA, SYes, (Order TPPA)No
SYPNBSyphilis Total Ab Bill Only 1No, (Bill Only)No
SYPPBSyphilis Total Ab Bill Only 2No, (Bill Only)No

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

If the syphilis total antibody result is nonreactive, billing will be captured under SYPNB.


If the syphilis total antibody result is reactive or equivocal, then the rapid plasma reagin (RPR) screen will be performed, and billing will be captured under SYPPB.


If the RPR screen is reactive, then the RPR titer will be performed at an additional charge.


If the RPR screen is nonreactive, then syphilis antibody Treponema pallidum particle agglutination testing will be performed at an additional charge.


See Syphilis Serology Algorithm in Special Instructions.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

SYPHT, RPRS: Multiplex Flow Immunoassay

RRPRQ: Flocculation/Agglutination

RTPPA: Particle Agglutination

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Syphilis Total Ab w/ Reflex, S

Aliases Lists additional common names for a test, as an aid in searching

ART (Automated Reagin Test)
Automated Reagin Test (ART)
Rapid Plasma Reagin (RPR)
RPR (Rapid Plasma Reagin)
Syphilis G, Serum
Syphilis Serology (RPR)
T. pallidum (Treponema pallidum)
Treponema pallidum (T. pallidum)