Test Catalog

Test ID: SMOGA    
Monoclonal Gammopathy Screen, Serum

Useful For Suggests clinical disorders or settings where the test may be helpful

Screening and diagnosis of monoclonal gammopathies including analysis of free light chains


Assessing the risk of progression from monoclonal gammopathy of undetermined significance to multiple myeloma

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
TPETotal ProteinYes, (Order TP)Yes
SPEProtein ElectrophoresisYes, (Order PEL)Yes
MPTSM-protein Isotype MALDI-TOF MS, SNoYes
KFLCKappa Free Light Chain, SYes, (Order FLCP)Yes
LFLCLambda Free Light Chain, SYes, (Order FLCP)Yes
KLRKappa/Lambda FLC RatioYes, (Order FLCP)Yes

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
IMFXImmunofixationYes, (Order IMFXO)No

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

This test includes total protein, serum protein electrophoresis, heavy and light chain typing (kappa and lambda), and quantitation of kappa and lambda free light chains.


If a light chain is identified without a corresponding heavy chain during initial testing, immunofixation with IgD and IgE antisera will be performed at an additional charge.


See Laboratory Screening Tests for Suspected Multiple Myeloma in Special Instructions.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

TPE: Biuret

SPE: Agarose Gel Electrophoresis

MPTS: Matrix-Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS)

KFLC, LFLC, KLR: Nephelometry

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Monoclonal Gammopathy Screen, S

Aliases Lists additional common names for a test, as an aid in searching

Mass Fix
Serum protein electrophoresis
Protein electrophoresis
MGUS Follow-up
Light chain deposition disease
MGUS screen
Myeloma screen
Kappa free light chain
Lambda free light chain
Free light chain ratio