Test Catalog

Test ID: DMS1    
Dementia, Autoimmune Evaluation, Serum

Useful For Suggests clinical disorders or settings where the test may be helpful

Investigating new onset dementia and cognitive impairment plus 1 or more of the following:

-Rapid onset and progression

-Fluctuating course

-Psychiatric accompaniments (psychosis, hallucinations)

-Movement disorder (myoclonus, tremor, dyskinesias)

-Headache

-Autoimmune stigmata (personal history or family history or signs of diabetes mellitus, thyroid disorder, vitiligo, poliosis [premature graying], myasthenia gravis, rheumatoid arthritis, systemic lupus erythematosus)

-Smoking history (20+ pack years) or other cancer risk factors

-History of cancer

-Inflammatory cerebral spinal fluid

-Neuroimaging findings atypical for degenerative etiology

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
ADMSIDementia, Interpretation, SNoYes
NMDCSNMDA-R Ab CBA, SNoYes
VGKCNeuronal (V-G) K+ Channel Ab, SNoYes
LG1CSLGI1-IgG CBA, SNoYes
CS2CSCASPR2-IgG CBA, SNoYes
GD65SGAD65 Ab Assay, SYesYes
GABCSGABA-B-R Ab CBA, SNoYes
AMPCSAMPA-R Ab CBA, SNoYes
ANN1SAnti-Neuronal Nuclear Ab, Type 1NoYes
ANN2SAnti-Neuronal Nuclear Ab, Type 2NoYes
ANN3SAnti-Neuronal Nuclear Ab, Type 3NoYes
AGN1SAnti-Glial Nuclear Ab, Type 1NoYes
PCAB2Purkinje Cell Cytoplasmic Ab Type 2NoYes
PCATRPurkinje Cell Cytoplasmic Ab Type TrNoYes
AMPHSAmphiphysin Ab, SNoYes
CCNN-Type Calcium Channel AbNoYes
CCPQP/Q-Type Calcium Channel AbNoYes
ARBIACh Receptor (Muscle) Binding AbNoYes
GANGAChR Ganglionic Neuronal Ab, SNoYes
CRMSCRMP-5-IgG, SNoYes

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
WBNParaneoplastic Autoantibody WBlot,SNoNo
CRMWSCRMP-5-IgG Western Blot, SYesNo
ABLOTAmphiphysin Western Blot, SNoNo
NMOFSNMO/AQP4 FACS, SYesNo
NMOTSNMO/AQP4 FACS Titer, SNoNo
AMPISAMPA-R Ab IF Titer Assay, SNoNo
GABISGABA-B-R Ab IF Titer Assay, SNoNo
NMDISNMDA-R Ab IF Titer Assay, SNoNo
PCABPPurkinje Cell Cytoplasmic Ab Type 1NoNo

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

If indirect immunofluorescence assay (IFA) (ANNA-1, ANNA-2, ANNA-3, PCA-2, PCA-Tr, Amphiphysin, CRMP-5-IgG, AGNA-1)) is indeterminate, paraneoplastic autoantibody Western blot is performed at an additional charge.

 

If client requests or if IFA patterns suggest CRMP-5-IgG, CRMP-5-IgG Western blot is performed at an additional charge.

 

If IFA patterns suggest amphiphysin antibody, amphiphysin Western blot is performed at an additional charge.

 

If IFA pattern suggest NMO/AQP4-IgG, NMO/AQP4-IgG FACS is performed at an additional charge.

 

If NMO/AQP4-IgG FACS screen assay requires further investigation, then NMO/AQP4-IgG FACS titration assay is performed at an additional charge.

 

If IFA pattern suggest AMPA-Receptor antibody and AMPA-Receptor antibody CBA is positive, AMPA-Receptor antibody IF titer assay is performed at an additional charge.

 

If IFA pattern suggest GABA-B-Receptor antibody and GABA-B-R Receptor Ab antibody is positive, GABA-B-R Receptor Ab antibody IF titer assay is performed at an additional charge.

 

If IFA pattern suggest NMDA-Receptor antibody and NMDA-Receptor Ab antibody CBA is positive, NMDA-Receptor Ab antibody IF titer assay is performed at an additional charge.

 

If IFA patterns suggest PCA-1, Purkinje Cell Cytoplasmic antibody Type 1 assay is performed at an additional charge.

 

See Dementia Autoimmune Evaluation Algorithm, Serum in Special Instructions

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

ANN1S, ANN2S, ANN3S, AGN1S, PCAB2, PCATR, AMPHS, CRMS, PCABP, NMDIS, AMPIS, GABIS: Indirect Immunofluorescence Assay (IFA)

VGKC, CCN, CCPQ, GANG, GD65S, ARBI: Radioimmunoassay (RIA)

WBN, ABLOT: Western Blot

AMPCS, GABCS, NMDCS, LG1CS, CS2CS: Cell Binding Assay (CBA)

NMOTS: Flow Cytometry

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

Dementia Autoimmune Eval, S

Aliases Lists additional common names for a test, as an aid in searching

ACh Receptor (Muscle) Binding Ab
AChR Ganglionic Ab
AMPA-R Ab CBA
Amphiphysin Ab
Anti-Glial Nuclear Ab, Type 1
Anti-Neuronal Nuclear Ab, Type 1
Anti-Neuronal Nuclear Ab, Type 2
Anti-Neuronal Nuclear Ab, Type 3
Cognitive decline
Cognitive impairment
CRMP-5-IgG
DEMES_x
GABA-B-R Ab CBA
Glutamic Acid Decarboxylase (GAD65)
N-type Voltage-Gated Calcium Channel Ab
Neuronal (V-G) K+ Channel Ab
NMDA-R Ab CBA
P/Q-type Voltage-Gated Calcium Channel Ab
Purkinje Cell Cytoplasmc Ab Type Tr
Purkinje Cell Cytoplasmic Ab Type 2
LGI1-IgG
CASPR2-IgG
Contactin-Associated Protein-Like-2 (CASPR2)-IgG
Leucine-Rich Glioma Inactived Protein-1 IgG