Web: | mayocliniclabs.com |
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Email: | mcl@mayo.edu |
Telephone: | 800-533-1710 |
International: | +1 855-379-3115 |
Values are valid only on day of printing. |
Confirming the autoimmune basis of a defect in neuromuscular transmission (eg, myasthenia gravis: MG, Lambert-Eaton syndrome: LES)
Distinguishing LES from 2 recognized autoimmune forms of MG
Raising the index of suspicion for cancer, particularly primary lung carcinoma (N-type calcium channel antibody)
Providing a quantitative autoantibody baseline for future comparisons in monitoring a patient's clinical course and response to immunomodulatory treatment
Test ID | Reporting Name | Available Separately | Always Performed |
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MGLEI | MG Lambert-Eaton Interpretation, S | No | Yes |
CCPQ | P/Q-Type Calcium Channel Ab | No | Yes |
CCN | N-Type Calcium Channel Ab | No | Yes |
ARBI | ACh Receptor (Muscle) Binding Ab | Yes | Yes |
ARMO | ACh Receptor (Muscle) Modulating Ab | No | Yes |
STR | Striational (Striated Muscle) Ab, S | Yes | Yes |
Test ID | Reporting Name | Available Separately | Always Performed |
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CRMWS | CRMP-5-IgG Western Blot, S | Yes | No |
GANG | AChR Ganglionic Neuronal Ab, S | No | No |
If acetylcholine receptor (AChR) modulating antibodies are > or =90% and striational antibodies are > or =1:120, then AChR ganglionic neuronal antibody and CRMP-5-IgG Western blot will be performed at an additional charge.
This evaluation is recommended for patients presenting with an acquired defect of neuromuscular transmission in whom the differential diagnosis includes Lambert-Eaton syndrome (LES). It is not recommended for patients with a past history of, or risk factors for, lung cancer and/or concurrent neurological symptoms/signs not attributable to LES; for those situations, order PAVAL / Paraneoplastic Autoantibody Evaluation, Serum. Testing for a newly recognized alternative antibody of myasthenia gravis (MG) (muscle-specific receptor tyrosine kinase) is indicated when all tests are negative.
See Myasthenia Gravis/Lambert Eaton Syndrome Diagnostic Algorithm in Special Instructions.
CCN, CCPQ, ARBI, ARMO, GANG: Radioimmunoassay (RIA)
STR: Enzyme Immunoassay (EIA)