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Test ID: MGL1    
Myasthenia Gravis (MG)/Lambert-Eaton Syndrome (LES) Evaluation

Useful For Suggests clinical disorders or settings where the test may be helpful

Confirming the autoimmune basis of a defect in neuromuscular transmission (eg, myasthenia gravis: MG, Lambert-Eaton syndrome: LES)

 

Distinguishing LES from 2 recognized autoimmune forms of MG

 

Raising the index of suspicion for cancer, particularly primary lung carcinoma (N-type calcium channel antibody)

 

Providing a quantitative autoantibody baseline for future comparisons in monitoring a patient's clinical course and response to immunomodulatory treatment

Profile Information A profile is a group of laboratory tests that are ordered and performed together under a single Mayo Test ID. Profile information lists the test performed, inclusive of the test fee, when a profile is ordered and includes reporting names and individual availability.

Test IDReporting NameAvailable SeparatelyAlways Performed
MGLEIMG Lambert-Eaton Interpretation, SNoYes
CCPQP/Q-Type Calcium Channel AbNoYes
CCNN-Type Calcium Channel AbNoYes
ARBIACh Receptor (Muscle) Binding AbYesYes
ARMOACh Receptor (Muscle) Modulating AbNoYes
STRStriational (Striated Muscle) Ab, SYesYes

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
CRMWSCRMP-5-IgG Western Blot, SYesNo
GANGAChR Ganglionic Neuronal Ab, SNoNo

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

If acetylcholine receptor (AChR) modulating antibodies are > or =90% and striational antibodies are > or =1:120, then AChR ganglionic neuronal antibody and CRMP-5-IgG Western blot will be performed at an additional charge.

 

This evaluation is recommended for patients presenting with an acquired defect of neuromuscular transmission in whom the differential diagnosis includes Lambert-Eaton syndrome (LES). It is not recommended for patients with a past history of, or risk factors for, lung cancer and/or concurrent neurological symptoms/signs not attributable to LES; for those situations, order PAVAL / Paraneoplastic Autoantibody Evaluation, Serum. Testing for a newly recognized alternative antibody of myasthenia gravis (MG) (muscle-specific receptor tyrosine kinase) is indicated when all tests are negative.

 

See Myasthenia Gravis/Lambert Eaton Syndrome Diagnostic Algorithm in Special Instructions.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

CCN, CCPQ, ARBI, ARMO, GANG: Radioimmunoassay (RIA)

STR: Enzyme Immunoassay (EIA)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.

Yes

Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

MG/LES Evaluation

Aliases Lists additional common names for a test, as an aid in searching

Acetylcholine Receptor (Muscle AChR) Antibodies
AChR (Acetylcholine Receptor)
Anti-skeletal Muscle Antibodies
Calcium Channel Blockers
Conotoxin (Receptor) Antibodies
Lambert-Eaton Myasthenic Syndrome (LEMS) Antibodies
Motor End-Plate Antibody
Motor Nerve Terminal Antibodies
Muscle Culture Antibodies
Muscle End-Plate Antibodies
Myasthenia Gravis Antibodies
Myoid Antibody
Striational (Striated Muscle) Antibodies
Voltage-Gated Calcium Channel (VGCC) Antibodies