Test ID: HCRC    
Hereditary Colon Cancer Multi-Gene Panel, Varies

Providing a comprehensive evaluation for hereditary colon cancer in patients with a personal or family history suggestive of a hereditary colon cancer syndrome

Serving as a second-tier test for patients in whom previous targeted gene mutation analyses for specific hereditary colorectal cancer-related genes were negative

Establishing a diagnosis of a hereditary colon cancer syndrome in some cases, allowing for targeted cancer surveillance of associated extra-colonic organs known to be at increased risk for cancer

Identifying mutations within genes known to be associated with increased risk for colon cancer allowing for predictive testing of at-risk family members

This test includes next-generation sequencing, Sanger sequencing, array comparative genomic hybridization, and multiplex ligation-dependent probe amplification to evaluate for the genes listed on the panel.

Prior Authorization is available for this assay; see Special Instructions

See Targeted Gene Regions Interrogated by Hereditary Colon Cancer Panel in Special Instructions for details regarding the targeted gene regions identified by this test.

The following algorithms are available in Special Instructions:

-Lynch Syndrome Testing Algorithm

-Colonic Polyposis Syndromes Testing Algorithm

• Molecular Genetics: Inherited Cancer Syndromes Patient Information
• Informed Consent for Genetic Testing
• Colonic Polyposis Syndromes Testing Algorithm
• Hereditary Colon Cancer Multi-Gene Panel Prior Authorization Ordering Instructions
• Targeted Genes Interrogated by Hereditary Colon Cancer Panel
• Lynch Syndrome Testing Algorithm
• Informed Consent for Genetic Testing (Spanish)

Custom Sequence Capture and Targeted Next-Generation Sequencing Followed by Polymerase Chain Reaction (PCR) and Sanger Sequencing and Gene Dosage Analysis by Array Comparative Genomic Hybridization (aCGH) or Multiplex Ligation-Dependent Probe Amplification (MLPA)