Test Catalog

Test ID: BLPF    
B-Cell Lymphoma, FISH, Varies

Useful For Suggests clinical disorders or settings where the test may be helpful

Detecting a neoplastic clone associated with the common chromosome abnormalities seen in patients with various B-cell lymphomas using blood or bone marrow specimens


Tracking known chromosome abnormalities and response to therapy in patients with B-cell neoplasms

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
_PBCTProbe, +2No, (Bill Only)No
_PADDProbe, +1No, (Bill Only)No
_PB02Probe, +2No, (Bill Only)No
_PB03Probe, +3No, (Bill Only)No
_IL25Interphases, <25No, (Bill Only)No
_I099Interphases, 25-99No, (Bill Only)No
_I300Interphases, >=100 No, (Bill Only)No

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

This test includes a charge for application of the first probe set (2 FISH probes) and professional interpretation of results. Additional charges will be incurred for all reflex probes performed. Analysis charges will be incurred based on the number of cells analyzed per probe set. If no cells are available for analysis, no analysis charges will be incurred.


When this test and flow cytometry testing for leukemia/lymphoma are ordered concurrently, the flow cytometry result will be utilized to determine if sufficient clonal B-cells are available for FISH testing. If the result does not identify a sufficient clonal B-cell population, this FISH test order will be canceled and no charges will be incurred.


If FISH testing proceeds, probes will be performed based on the lymphoma subtype suspected/identified utilizing the table "Common Chromosome Abnormalities in B-cell Lymphomas" located in Clinical Information.


If the patient is being tracked for known abnormalities, indicate which probes should be used.


The following probe sets are available within this B-cell lymphoma FISH profile:

-8q24.1 rearrangement, MYC

-t(8;14), MYC/IGH

-18q21 rearrangement, BCL2

-3q27 rearrangement, BCL6

-t(11;14), CCND1/IGH

-17p deletion, TP53/D17Z1

-7q deletion, D7Z1/7q32

-18q21 rearrangement, MALT1


Marginal zone lymphoma (MZL) can be evaluated via probes for specific subtypes, as follows: mucosa-associated lymphoid tissue (MALT) lymphoma or extra-nodal marginal zone lymphoma (ENMZL) using the MALT1 rearrangement probe and splenic marginal zone lymphoma using probes for 7q deletion and 17p deletion. If no MZL subtype is provided, we will evaluate using probes for MALT1, 7q deletion and 17p deletion.


See Bone Marrow Staging for Known or Suspected Malignant Lymphoma Algorithm in Special Instructions.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

Fluorescence In Situ Hybridization (FISH)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

B-cell Lymphoma, FISH, B/BM

Aliases Lists additional common names for a test, as an aid in searching

17p- (17p deletion) or TP53
BCL2 (18q21) rearrangement
BCL6 (3q27) rearrangement
Burkitt Lymphoma
Burkitt-like Lymphoma
Diffuse Large Cell Lymphoma/"Double Hit"
Follicular Lymphoma
MALT (18q21) rearrangement
MALT Lymphoma
Mantle Cell Lymphoma (MCL)
MYC (8q24.1) rearrangement
Splenic Marginal Zone Lymphoma
t(11;14)(q13;q32) - CCND1/IGH
t(2;8)(p12;q24) - IGK/MYC
t(8;14)(q24.1;q32) - MYC/IGH
t(8;22)(q24.1;q11.2) - MYC/IGL
Extra-nodal Marginal Zone Lymphoma (ENMZL)
Triple hit lymphoma