Test Catalog

Test ID: BLPF    
B-Cell Lymphoma, FISH, Blood or Bone Marrow

Useful For Suggests clinical disorders or settings where the test may be helpful

Detecting a neoplastic clone associated with the common chromosome abnormalities seen in patients with various B-cell lymphomas using blood or bone marrow specimens


Tracking known chromosome abnormalities and response to therapy in patients with B-cell neoplasms

Reflex Tests Lists tests that may or may not be performed, at an additional charge, depending on the result and interpretation of the initial tests.

Test IDReporting NameAvailable SeparatelyAlways Performed
_PBCTProbe, +2No, (Bill Only)No
_PADDProbe, +1No, (Bill Only)No
_PB02Probe, +2No, (Bill Only)No
_PB03Probe, +3No, (Bill Only)No
_IL25Interphases, <25No, (Bill Only)No
_I099Interphases, 25-99No, (Bill Only)No
_I300Interphases, >=100 No, (Bill Only)No

Testing Algorithm Delineates situations when tests are added to the initial order. This includes reflex and additional tests.

This test includes a charge for application of the first probe set (2 FISH probes) and professional interpretation of results. Additional charges will be incurred for all reflex probes performed. Analysis charges will be incurred based on the number of cells analyzed per probe set. If no cells are available for analysis, no analysis charges will be incurred.


Depending on the lymphoma subtype suspected, the most appropriate probes to order are listed in the table "Common Chromosome Abnormalities in B-cell Lymphomas" in Clinical Information.


If the patient is being tracked for known abnormalities, indicate which probes should be used.


If no probes (or lymphoma subtype) are specified at the time of order, a panel of the following probe sets will be performed:

-8q24.1 rearrangement, MYC

-t(8;14), MYC/IGH

-18q21 rearrangement, BCL2

-3q27 rearrangement, BCL6

-t(11;14), CCND1/IGH

-17p-, TP53/D17Z1

-18q21 rearrangement, MALT1


See Bone Marrow Staging for Known or Suspected Malignant Lymphoma Algorithm in Special Instructions.

Special Instructions Library of PDFs including pertinent information and forms related to the test

Method Name A short description of the method used to perform the test

Fluorescence In Situ Hybridization (FISH)

NY State Available Indicates the status of NY State approval and if the test is orderable for NY State clients.


Reporting Name Lists a shorter or abbreviated version of the Published Name for a test

B-cell Lymphoma, FISH, B/BM

Aliases Lists additional common names for a test, as an aid in searching

17p- (17p deletion) or TP53
BCL2 (18q21) rearrangement
BCL6 (3q27) rearrangement
Burkitt Lymphoma
Burkitt-like Lymphoma
Diffuse Large Cell Lymphoma/"Double Hit"
Follicular Lymphoma
MALT (18q21) rearrangement
MALT Lymphoma
Mantle Cell Lymphoma (MCL)
MYC (8q24.1) rearrangement
Splenic Marginal Zone Lymphoma
t(11;14)(q13;q32) - CCND1/IGH
t(11;18)(q21;q21) - BIRC3/MALT1
t(14;18)(q32;q21) - IGH/MALT1
t(14;18)(q32;q21) - IGH/BCL2
t(2;8)(p12;q24) - IGK/MYC
t(8;14)(q24.1;q32) - MYC/IGH
t(8;22)(q24.1;q11.2) - MYC/IGL