Test Catalog

Test ID: FINTA    
Interleukin 1-Alpha

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

The Interleukins belong to the family termed cytokines.  They are peptides used by immune and inflammatory cells to communicate and control cell operations. The cytokines have some similar actions to the Growth Factors but Growth Factors regulate proliferation of non-immune cells.  Interleukin 1a is a 17,500 molecular weight peptide derived primarily from macrophages, fibroblasts, endothelial cells, and B cells.  The major target cells are T and B cells, Fibroblasts, and Hepatocytes.  Interleukin 1a shares a receptor with Interleukin 1b although they are significantly different structurally.  Interleukin 1a promotes antigen specific immune responses, inflammation, Prostaglandin secretion, Colony Stimulating Factors, proteoglycanase, collagenase, and gelatinase activity, and release of Interleukin 2 from T cells.  Levels are stimulated by liposaccharide, endotoxins, inflammatory agents, lectin, Tumor Necrosis Factor, and Interferons.  Levels are suppressed by Corticosteroids, Prostaglandin E2, and suppressant lymphocytes.

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Less than 3.9 pg/mL

Clinical Reference Recommendations for in-depth reading of a clinical nature

1. JT Whicher and SW Evans. Cytokines in Disease. Clinical Chemistry 36: 1269-1281, 1990.

2. MP Bevilacqua, JS Pober, GR Majeau, W Fiers, RS Cotran, and MA Gimbrone. Recombinant Tumor Necrosis Factor Induced Pro-Coagulant Activity in Cultured Human Vascular Endothelium: Characterization and Comparison with Action of Interleukin-1. Proceedings of the National Academy of Science 83: 4533-4537, 1986.